Zuotin Related Factor 1 (ZRF1) Antibody – Rabbit Polyclonal

DNAJC2: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Chaperone; DNA replication

Chromosomal Location of Human Ortholog: 4q11

Cellular Component: cytoplasm; cytosol; nuclear membrane; nucleus

Molecular Function: chromatin binding; histone binding; Hsp70 protein binding; ubiquitin binding

Biological Process: DNA replication; negative regulation of cell growth; positive regulation of transcription, DNA-dependent