Baculovirus CD163 Recombinant Protein – Cat# MBS206746

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

CD163 Baculovirus Recombinant Protein

Name: CD163 Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206746
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206746

CD163, also known as scavenger receptor cysteine-rich type 1 protein M130 isoform a, is a scavenger receptor for the hemoglobin-haptoglobin complex that is essential in liver, spleen and circulation. This protein is generated by ectodomain shedding of the… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD163, Recombinant Protein

Full Product Name

CD163, 42-1050aa, Human, His-tag, Baculovirus

Product Gene Name

CD163 recombinant protein

Product Synonym Names

Scavenger receptor cysteine-rich type 1 protein M130 isoform; CD163; M130; MM130; SCARI1

Sequence

SSLGGTDKEL RLVDGENKCS GRVEVKVQEE WGTVCNNGWS MEAVSVICNQ LGCPTAIKAP GWANSSAGSG RIWMDHVSCR GNESALWDCK HDGWGKHSNC THQQDAGVTC SDGSNLEMRL TRGGNMCSGR IEIKFQGRWG TVCDDNFNID HASVICRQLE CGSAVSFSGS SNFGEGSGPI WFDDLICNGN ESALWNCKHQ GWGKHNCDHA EDAGVICSKG ADLSLRLVDG VTECSGRLEV RFQGEWGTIC DDGWDSYDAA VACKQLGCPT AVTAIGRVNA SKGFGHIWLD SVSCQGHEPA IWQCKHHEWG KHYCNHNEDA GVTCSDGSDL ELRLRGGGSR CAGTVEVEIQ RLLGKVCDRG WGLKEADVVC RQLGCGSALK TSYQVYSKIQ ATNTWLFLSS CNGNETSLWD CKNWQWGGLT CDHYEEAKIT CSAHREPRLV GGDIPCSGRV EVKHGDTWGS ICDSDFSLEA ASVLCRELQC GTVVSILGGA HFGEGNGQIW AEEFQCEGHE SHLSLCPVAP RPEGTCSHSR DVGVVCSRYT EIRLVNGKTP CEGRVELKTL GAWGSLCNSH WDIEDAHVLC QQLKCGVALS TPGGARFGKG NGQIWRHMFH CTGTEQHMGD CPVTALGASL CPSEQVASVI CSGNQSQTLS SCNSSSLGPT RPTIPEESAV ACIESGQLRL VNGGGRCAGR VEIYHEGSWG TICDDSWDLS DAHVVCRQLG CGEAINATGS AHFGEGTGPI WLDEMKCNGK ESRIWQCHSH GWGQQNCRHK EDAGVICSEF MSLRLTSEAS REACAGRLEV FYNGAWGTVG KSSMSETTVG VVCRQLGCAD KGKINPASLD KAMSIPMWVD NVQCPKGPDT LWQCPSSPWE KRLASPSEET WITCDNKIRL QEGPTSCSGR VEIWHGGSWG TVCDDSWDLD DAQVVCQQLG CGPALKAFKE AEFGQGTGPI WLNEVKCKGN ESSLWDCPAR RWGHSECGHK EDAAVNCTDI SVQKTPQKAT TGRSSRQSSH HHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4).

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2-8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

109.8kDa (1015aa)

OMIM

Z22968 mRNA

3D Structure

ModBase 3D Structure for Q86VB7

Tag Information

His-tag

Domain

42-1050aa

Endotoxin Level

< 1 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for CD163 recombinant protein

Immunology

Applications Tested/Suitable for CD163 recombinant protein

SDS-PAGE

Product References and Citations for CD163 recombinant protein

Droste A., et al, (1999) Biochem. Biophys. Res. Commun. 256:110-113.; Stover CM., et al, (2000) Cytogenet. Cell Genet. 90:246-247.

Other Notes

Small volumes of CD163 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD163 purchase

MBS206746 is a recombinant protein targeting CD163. Also known as CD163, 42-1050aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CD163. It may not necessarily be applicable to this product.

NCBI GI #

344179110

NCBI GeneID

9332

NCBI Accession #

NP_004235

UniProt Primary Accession #

Q86VB7

UniProt Secondary Accession #

Q07898; Q07899; Q07900; Q07901; Q2VLH7; C9JIG2

UniProt Related Accession #

Q86VB7

GenBank Nucleotide #

NM_004244.5

NCBI Official Full Name

scavenger receptor cysteine-rich type 1 protein M130 isoform a

NCBI Official Synonym Full Names

CD163 molecule

NCBI Official Symbol

CD163

NCBI Official Synonym Symbols

M130; MM130; SCARI1

UniProt Protein Name

Scavenger receptor cysteine-rich type 1 protein M130

UniProt Synonym Protein Names

Hemoglobin scavenger receptor; CD_antigen: CD163

Protein Family

Scavenger receptor cysteine-rich type 1 protein

UniProt Gene Name

CD163

UniProt Synonym Gene Names

M130; sCD163

NCBI Protein Information

scavenger receptor cysteine-rich type 1 protein M130

NCBI Summary for CD163

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

UniProt Comments for CD163

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Research Articles on CD163

1. The cumulative incidence of de novo-onset cGVHD was higher in patients with higher plasma soluble CD163 concentrations at day 80 than those with lower concentrations (75% versus 40%, P = .018). The cumulative incidence of de novo- or quiescent-onset cGVHD did not differ statistically according to concentrations of the 3 other proteins at day 80.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD163 recombinant protein

Reference Product	PubMed Publications
CD68 recombinant protein	>703 publications with CD163 and CD68
IL10 recombinant protein	>161 publications with CD163 and IL10
CSF1R recombinant protein	>7 publications with CD163 and CSF1R
TYROBP recombinant protein	>2 publications with CD163 and TYROBP
C1QA recombinant protein	>1 publications with CD163 and C1QA
VSIG4 recombinant protein	>1 publications with CD163 and VSIG4
C1QB recombinant protein	>1 publications with CD163 and C1QB

Pathways associated with CD163 recombinant protein

Products by Pathway	Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
Scavenging Of Heme From Plasma Pathway antibodies	Scavenging Of Heme From Plasma Pathway Diagram
Vesicle-mediated Transport Pathway antibodies	Vesicle-mediated Transport Pathway Diagram

Diseases associated with CD163 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>727 publications with CD163 and Inflammation
Necrosis Antibodies	>262 publications with CD163 and Necrosis
Liver Diseases Antibodies	>133 publications with CD163 and Liver Diseases
Disease Models, Animal Antibodies	>126 publications with CD163 and Disease Models, Animal
Fibrosis Antibodies	>116 publications with CD163 and Fibrosis
Lung Diseases Antibodies	>103 publications with CD163 and Lung Diseases
Adenocarcinoma Antibodies	>87 publications with CD163 and Adenocarcinoma
Hemorrhage Antibodies	>67 publications with CD163 and Hemorrhage
Heart Diseases Antibodies	>67 publications with CD163 and Heart Diseases
Kidney Diseases Antibodies	>57 publications with CD163 and Kidney Diseases

Organs/Tissues associated with CD163 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1138 publications with CD163 and Blood
Vascular Antibodies	>281 publications with CD163 and Vascular
Liver Antibodies	>211 publications with CD163 and Liver
Bone Antibodies	>197 publications with CD163 and Bone
Skin Antibodies	>191 publications with CD163 and Skin
Brain Antibodies	>153 publications with CD163 and Brain
Lung Antibodies	>141 publications with CD163 and Lung
Kidney Antibodies	>91 publications with CD163 and Kidney
Heart Antibodies	>90 publications with CD163 and Heart
Connective Tissue Antibodies	>90 publications with CD163 and Connective Tissue