Baculovirus SEMA7A Recombinant Protein – Cat# MBS206770

SEMA7A Baculovirus Recombinant Protein

Name: SEMA7A Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206770
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206770

SEMA7A, also known as semaphorin-7A isoform 1, is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. It promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SEMA7A, Recombinant Protein

Full Product Name

SEMA7A, 45-648aa, Human, hIgG-His-tag, Baculovirus

Product Gene Name

SEMA7A recombinant protein

Product Synonym Names

Semaphorin-7A isoform 1; SEMA7A; CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL

Sequence

ADPQGHLRSG PRIFAVWKGH VGQDRVDFGQ TEPHTVLFHE PGSSSVWVGG RGKVYLFDFP EGKNASVRTV NIGSTKGSCL DKRDCENYIT LLERRSEGLL ACGTNARHPS CWNLVNGTVV PLGEMRGYAP FSPDENSLVL FEGDEVYSTI RKQEYNGKIP RFRRIRGESE LYTSDTVMQN PQFIKATIVH QDQAYDDKIY YFFREDNPDK NPEAPLNVSR VAQLCRGDQG GESSLSVSKW NTFLKAMLVC SDAATNKNFN RLQDVFLLPD PSGQWRDTRV YGVFSNPWNY SAVCVYSLGD IDKVFRTSSL KGYHSSLPNP RPGKCLPDQQ PIPTETFQVA DRHPEVAQRV EPMGPLKTPL FHSKYHYQKV AVHRMQASHG ETFHVLYLTT DRGTIHKVVE PGEQEHSFAF NIMEIQPFRR AAAIQTMSLD AERRKLYVSS QWEVSQVPLD LCEVYGGGCH GCLMSRDPYC GWDQGRCISI YSSERSVLQS INPAEPHKEC PNPKPDKAPL QKVSLAPNSR YYLSCPMESR HATYSWRHKE NVEQSCEPGH QSPNCILFIE NLTAQQYGHY FCEAQEGSYF REAQHWQLLP EDGIMAEHLL GHACALALEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

95.7kDa (846aa) 70-100kDa (SDS-PAGE under reducing conditions)

OMIM

AF030698 mRNA

3D Structure

ModBase 3D Structure for O75326

Antigen Species

Human

Tag Information

hIgG-His-tag

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for SEMA7A recombinant protein

Cardiovascular

Applications Tested/Suitable for SEMA7A recombinant protein

SDS-PAGE

Product References and Citations for SEMA7A recombinant protein

Scott GA., et al. (2008) J Invest Dermatol. 128:151-161.; Pasterkamp RJ., et al. (2003) Nature. 424:398-405.

Other Notes

Small volumes of SEMA7A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEMA7A purchase

MBS206770 is a recombinant protein targeting SEMA7A. Also known as SEMA7A, 45-648aa, Human, hIgG-His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA7A. It may not necessarily be applicable to this product.

NCBI GI #

4504237

NCBI GeneID

8482

NCBI Accession #

NP_003603

UniProt Primary Accession #

O75326

UniProt Secondary Accession #

Q1XE81; Q1XE82; Q1XE83; Q1XE84; Q3MIY5; B4DDP7; F5H1S0

UniProt Related Accession #

O75326

GenBank Nucleotide #

NM_003612.4

NCBI Official Full Name

semaphorin-7A isoform 1 preproprotein

NCBI Official Synonym Full Names

semaphorin 7A (John Milton Hagen blood group)

NCBI Official Symbol

SEMA7A

NCBI Official Synonym Symbols

JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1

UniProt Protein Name

Semaphorin-7A

UniProt Synonym Protein Names

CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108

Protein Family

Semaphorin

UniProt Gene Name

SEMA7A

UniProt Synonym Gene Names

CD108; SEMAL; Sema K1; Sema L

NCBI Protein Information

semaphorin-7A

NCBI Summary for SEMA7A

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

UniProt Comments for SEMA7A

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

Research Articles on SEMA7A

1. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SEMA7A recombinant protein

Reference Product	PubMed Publications
PLXNC1 recombinant protein	>5 publications with SEMA7A and PLXNC1
PLXNB1 recombinant protein	>4 publications with SEMA7A and PLXNB1
TGFB1 recombinant protein	>4 publications with SEMA7A and TGFB1
NRP1 recombinant protein	>1 publications with SEMA7A and NRP1
NRP2 recombinant protein	>1 publications with SEMA7A and NRP2
CHI3L1 recombinant protein	>1 publications with SEMA7A and CHI3L1
ITGB1 recombinant protein	>1 publications with SEMA7A and ITGB1

Pathways associated with SEMA7A recombinant protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Other Semaphorin Interactions Pathway antibodies	Other Semaphorin Interactions Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with SEMA7A recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>23 publications with SEMA7A and Inflammation
Lung Diseases Antibodies	>9 publications with SEMA7A and Lung Diseases
Lung Injury Antibodies	>6 publications with SEMA7A and Lung Injury
Fibrosis Antibodies	>5 publications with SEMA7A and Fibrosis
Cardiovascular Diseases Antibodies	>5 publications with SEMA7A and Cardiovascular Diseases
Necrosis Antibodies	>4 publications with SEMA7A and Necrosis
Pneumonia Antibodies	>3 publications with SEMA7A and Pneumonia
Heart Diseases Antibodies	>3 publications with SEMA7A and Heart Diseases
Edema Antibodies	>2 publications with SEMA7A and Edema
Breast Neoplasms Antibodies	>2 publications with SEMA7A and Breast Neoplasms

Organs/Tissues associated with SEMA7A recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>33 publications with SEMA7A and Blood
Brain Antibodies	>27 publications with SEMA7A and Brain
Lung Antibodies	>13 publications with SEMA7A and Lung
Bone Antibodies	>12 publications with SEMA7A and Bone
Embryonic Tissue Antibodies	>10 publications with SEMA7A and Embryonic Tissue
Skin Antibodies	>7 publications with SEMA7A and Skin
Vascular Antibodies	>5 publications with SEMA7A and Vascular
Bone Marrow Antibodies	>5 publications with SEMA7A and Bone Marrow
Connective Tissue Antibodies	>5 publications with SEMA7A and Connective Tissue
Spleen Antibodies	>5 publications with SEMA7A and Spleen