MS4A1/CD20 Baculovirus Recombinant Protein

MS4A1, also known as B-lymphocyte antigen CD20, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase and progressively increasing in concentration until maturity. It is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. It plays a role in the microenvironmental interactions of B cells. This structurally unique phosphoprotein plays a role in the regulation of human B cell proliferation and differentiation. It was strongly phosphorylated on resting B cells after CDw40 stimulation, suggesting that it may be functionally regulated by a protein kinase. Recombinant human MS4A1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Kuijpers TW., et al. (2010) J Clin Invest. 120:214-222.; Pavlasova G., et al. (2016) Blood. 128:1609-1613.

Small volumes of MS4A1/CD20 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS206784 is a recombinant protein targeting MS4A1/CD20. Also known as MS4A1/CD20, 210-297aa, Human, His-tag, Baculovirus. Host: Baculovirus.