• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

T-Cell Lymphoma Invasion and Metastasis Inducing Protein 1 (TIAM1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2068168
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2068168 is an antibody targeting TIAM1. Also known as FITC-Linked Polyclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$270 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1), Polyclonal Antibody
Full Product Name
FITC-Linked Polyclonal Antibody to T-Cell Lymphoma Invasion And Metastasis Inducing Protein 1 (TIAM1)
Product Gene Name
anti-TIAM1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Concentration
500ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: TIAM1 (MBS2032162)
FITC Conjugated Antibody: TIAM1 (MBS2068168)
Matching Pairs
FITC Conjugated Antibody: TIAM1 (MBS2068168)
Immunogen: TIAM1 (MBS2033280)
Molecular Weight
170,580 Da
OMIM
U16296 mRNA
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
TIAM1 (Asp1261~Lys1397)
Conjugation
FITC
Cross Reactivity
Human
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032162
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TIAM1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Other Notes

Small volumes of anti-TIAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TIAM1. It may not necessarily be applicable to this product.

NCBI GI #
115583670
NCBI GeneID
7074
NCBI Accession #
NP_003244.2
UniProt Secondary Accession #
Q17RT7; B7ZLR6; F5GZ53
UniProt Related Accession #
Q13009
GenBank Nucleotide #
NM_003253.2
NCBI Official Full Name
T-lymphoma invasion and metastasis-inducing protein 1
NCBI Official Synonym Full Names
T-cell lymphoma invasion and metastasis 1
NCBI Official Symbol
TIAM1
UniProt Protein Name
T-lymphoma invasion and metastasis-inducing protein 1
Protein Family
T-lymphoma invasion and metastasis-inducing protein
UniProt Gene Name
TIAM1
UniProt Synonym Gene Names
TIAM-1
NCBI Protein Information
T-lymphoma invasion and metastasis-inducing protein 1

UniProt Comments for TIAM1

TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction
Show more

Research Articles on TIAM1

1. Tiam1 expression significantly increased in cholangiocarcinoma tissues, and increased along with the degree of malignancy of cholangiocarcinoma. Targeted silencing Tiam1 expression could inhibit proliferation and migration activity of cholangiocarcinoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TIAM1 antibody

 Reference Product  PubMed Publications
 RAC1 antibody  >178 publications with TIAM1 and RAC1
 CDC42 antibody  >62 publications with TIAM1 and CDC42
 SRC antibody  >18 publications with TIAM1 and SRC
 PARD3 antibody  >11 publications with TIAM1 and PARD3
 RAC3 antibody  >4 publications with TIAM1 and RAC3
 ARF6 antibody  >3 publications with TIAM1 and ARF6
 EPHB2 antibody  >2 publications with TIAM1 and EPHB2
 EPHA2 antibody  >2 publications with TIAM1 and EPHA2
 PARD6A antibody  >1 publications with TIAM1 and PARD6A

Pathways associated with anti-TIAM1 antibody

 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram

Diseases associated with anti-TIAM1 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >78 publications with TIAM1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >23 publications with TIAM1 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >21 publications with TIAM1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >14 publications with TIAM1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >13 publications with TIAM1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >11 publications with TIAM1 and Liver Neoplasms
 Inflammation Antibodies  >11 publications with TIAM1 and Inflammation
 Neurobehavioral Manifestations Antibodies  >9 publications with TIAM1 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >9 publications with TIAM1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >7 publications with TIAM1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-TIAM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >40 publications with TIAM1 and Brain
 Blood Antibodies  >32 publications with TIAM1 and Blood
 Vascular Antibodies  >29 publications with TIAM1 and Vascular
 Lung Antibodies  >27 publications with TIAM1 and Lung
 Lymph Node Antibodies  >16 publications with TIAM1 and Lymph Node
 Nerve Antibodies  >16 publications with TIAM1 and Nerve
 Skin Antibodies  >12 publications with TIAM1 and Skin
 Kidney Antibodies  >11 publications with TIAM1 and Kidney
 Bone Antibodies  >11 publications with TIAM1 and Bone
 Embryonic Tissue Antibodies  >7 publications with TIAM1 and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000