Glutamyl Prolyl Trna Synthetase (EPRS) Antibody – Rabbit Polyclonal

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]

EPRS: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Interacts with DUS2L.

Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; membrane; ribonucleoprotein complex

Molecular Function: glutamate-tRNA ligase activity; GTPase binding; proline-tRNA ligase activity; protein binding

Biological Process: glutamyl-tRNA aminoacylation; negative regulation of translation; prolyl-tRNA aminoacylation; protein complex assembly; tRNA aminoacylation for protein translation