Ephrin A1 (EFNA1) Antibody – Rabbit Polyclonal

EFNA1: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor; Tumor suppressor

Chromosomal Location of Human Ortholog: 3 F1|3 39.04 cM

Cellular Component: anchored to plasma membrane

Molecular Function: ephrin receptor binding

Biological Process: activation of MAPK activity; axon guidance; cell migration; ephrin receptor signaling pathway; MAPKKK cascade; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; notochord formation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of angiogenesis; regulation of axonogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; regulation of peptidyl-tyrosine phosphorylation