Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) Antibody – Rabbit Polyclonal

This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 19 B|19 12.86 cM

Cellular Component: extracellular space; Golgi apparatus; secretory granule

Molecular Function: endopeptidase activity; peptidase activity; peptide binding; serine-type endopeptidase activity

Biological Process: anterior/posterior pattern formation; cytokine biosynthetic process; determination of left/right symmetry; embryo implantation; embryonic gut development; embryonic skeletal development; heart development; kidney development; limb morphogenesis; peptide biosynthetic process; peptide hormone processing; protein processing; respiratory tube development; signal peptide processing; viral infectious cycle