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Docking Protein 3 (DOK3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2076414
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MBS2076414 is an antibody targeting DOK3. Also known as APC-Linked Polyclonal Antibody to Docking Protein 3 (DOK3). Reactive in Mouse. Host: Rabbit. More details

$340 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Docking Protein 3 (DOK3), Polyclonal Antibody
Full Product Name
APC-Linked Polyclonal Antibody to Docking Protein 3 (DOK3)
Product Gene Name
anti-DOK3 antibody
Product Synonym Names
DOKL; Downstream of tyrosine kinase 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Concentration
>=100ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: DOK3 (MBS2013697)
APC Conjugated Antibody: DOK3 (MBS2076414)
Matching Pairs
APC Conjugated Antibody: DOK3 (MBS2076414)
Immunogen: DOK3 (MBS2018810)
Molecular Weight
48,027 Da
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
DOK3 (Glu160~Glu409)
Conjugation
APC
Cross Reactivity
Mouse
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2013697
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-DOK3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Other Notes

Small volumes of anti-DOK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK3. It may not necessarily be applicable to this product.

NCBI GI #
7305003
NCBI GeneID
27261
NCBI Accession #
NP_038767.1
UniProt Related Accession #
Q9QZK7
GenBank Nucleotide #
NM_013739.2
NCBI Official Full Name
docking protein 3
NCBI Official Synonym Full Names
docking protein 3
NCBI Official Symbol
Dok3
NCBI Official Synonym Symbols
Dokl; AI450713
UniProt Protein Name
Docking protein 3
UniProt Synonym Protein Names
Downstream of tyrosine kinase 3; p62(dok)-like protein; DOK-L
Protein Family
Docking protein
UniProt Gene Name
Dok3
UniProt Synonym Gene Names
Dokl; DOK-L
NCBI Protein Information
docking protein 3

UniProt Comments for DOK3

DOK3: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with SHIP. May modulate Abl function. Upon tyrosine phosphorylation, Dok3 interacts with CSK and SHIP via their SH2 domains. Both pY381 and pY398 are required for interaction with SHIP. Only pY381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Does not interact with RasGAP. Four isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 13|13 B1

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: Ras protein signal transduction
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Research Articles on DOK3

1. we demonstrate that CpG treatment leads to ubiquitin-mediated degradation of DOK3 via interaction with an E3 ligase TNFR-associated factor 6 (TRAF6).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DOK3 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-DOK3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with DOK3 and Inflammation
 Hypertension Antibodies  >1 publications with DOK3 and Hypertension
 Adenocarcinoma Antibodies  >1 publications with DOK3 and Adenocarcinoma
 Necrosis Antibodies  >1 publications with DOK3 and Necrosis
 Hyperplasia Antibodies  >1 publications with DOK3 and Hyperplasia
 Lung Neoplasms Antibodies  >1 publications with DOK3 and Lung Neoplasms

Organs/Tissues associated with anti-DOK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with DOK3 and Blood
 Lung Antibodies  >3 publications with DOK3 and Lung
 Bone Marrow Antibodies  >2 publications with DOK3 and Bone Marrow
 Bone Antibodies  >2 publications with DOK3 and Bone
 Thymus Antibodies  >1 publications with DOK3 and Thymus
 Heart Antibodies  >1 publications with DOK3 and Heart
 Lymph Node Antibodies  >1 publications with DOK3 and Lymph Node
 Spleen Antibodies  >1 publications with DOK3 and Spleen
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