Lysine Specific Demethylase 4a (KDM4A) Antibody – Rabbit Polyclonal

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family.

Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p34.2-p34.1

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding

Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent