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Glycine-N-Methyltransferase (GNMT) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2078675
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MBS2078675 is an antibody targeting GNMT. Also known as APC-Linked Polyclonal Antibody to Glycine-N-Methyltransferase (GNMT). Reactive in Human, Mouse, Rat, Pig. Host: Rabbit. More details

$330 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glycine-N-Methyltransferase (GNMT), Polyclonal Antibody
Full Product Name
APC-Linked Polyclonal Antibody to Glycine-N-Methyltransferase (GNMT)
Product Gene Name
anti-GNMT antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Pig
Concentration
>=100ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: GNMT (MBS2032748)
APC Conjugated Antibody: GNMT (MBS2078675)
Matching Pairs
APC Conjugated Antibody: GNMT (MBS2078675)
Immunogen: GNMT (MBS2033388)
Molecular Weight
32,549 Da
3D Structure
ModBase 3D Structure for P13255
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
GNMT (Val2~Asp295)
Conjugation
APC
Cross Reactivity
Human
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032748
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-GNMT antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Other Notes

Small volumes of anti-GNMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GNMT. It may not necessarily be applicable to this product.

NCBI GI #
8567354
NCBI GeneID
25134
NCBI Accession #
NP_058780.1
UniProt Primary Accession #
P13255
UniProt Related Accession #
P13255
GenBank Nucleotide #
NM_017084.1
NCBI Official Full Name
glycine N-methyltransferase
NCBI Official Synonym Full Names
glycine N-methyltransferase
NCBI Official Symbol
Gnmt
UniProt Protein Name
Glycine N-methyltransferase
UniProt Synonym Protein Names
Folate-binding protein
Protein Family
Glycine N-methyltransferase
UniProt Gene Name
Gnmt
NCBI Protein Information
glycine N-methyltransferase

NCBI Summary for GNMT

catalyzes the conversion of S-adenosyl-L-methionine and glycine to S-adenosyl-L-homocysteine and sarcosine; involved in S-adenosylmethionine and folate metabolism [RGD, Feb 2006]

UniProt Comments for GNMT

GNMT: Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Defects in GNMT are the cause of glycine N- methyltransferase deficiency (GNMT deficiency); also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.20; Methyltransferase

Chromosomal Location of Human Ortholog: 9q12

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: folic acid binding; glycine binding; glycine N-methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: folic acid metabolic process; glycine metabolic process; glycogen metabolic process; methionine metabolic process; one-carbon compound metabolic process; protein homotetramerization; protein tetramerization; regulation of gluconeogenesis; S-adenosylhomocysteine metabolic process; S-adenosylmethionine metabolic process; selenium metabolic process
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Research Articles on GNMT

1. Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GNMT antibody

 Products by Pathway  Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram

Diseases associated with anti-GNMT antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >51 publications with GNMT and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >39 publications with GNMT and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >29 publications with GNMT and Liver Neoplasms
 Adenocarcinoma Antibodies  >26 publications with GNMT and Adenocarcinoma
 Disease Models, Animal Antibodies  >23 publications with GNMT and Disease Models, Animal
 Fatty Liver Antibodies  >16 publications with GNMT and Fatty Liver
 Hepatitis Antibodies  >12 publications with GNMT and Hepatitis
 Hyperhomocysteinemia Antibodies  >8 publications with GNMT and Hyperhomocysteinemia
 Hepatitis, Chronic Antibodies  >8 publications with GNMT and Hepatitis, Chronic
 Liver Cirrhosis Antibodies  >8 publications with GNMT and Liver Cirrhosis

Organs/Tissues associated with anti-GNMT antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >121 publications with GNMT and Liver
 Kidney Antibodies  >7 publications with GNMT and Kidney
 Lung Antibodies  >3 publications with GNMT and Lung
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