WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody – Rabbit Polyclonal

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]

WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.

Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Wnk family

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function: ATP binding; chloride channel inhibitor activity; phosphatase binding; protein binding; protein kinase activator activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity

Biological Process: ion transport; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; protein amino acid phosphorylation; regulation of cellular process; regulation of sodium ion transport

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic