TANK Binding Kinase 1 (TBK1) Antibody – Rabbit Polyclonal

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]

TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Protein type: EC 2.7.11.1; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 12q14.2

Cellular Component: cytoplasm; cytosol; endosome membrane

Molecular Function: phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; interferon type I production; negative regulation of interferon type I production; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; response to virus

Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 4