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Rho Guanine Nucleotide Exchange Factor 7 (ARHGEF7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2081874
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2081874 is an antibody targeting ARHGEF7. Also known as FITC-Linked Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 7 (ARHGEF7). Reactive in Human, Rat. Host: Rabbit. More details

$280 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rho Guanine Nucleotide Exchange Factor 7 (ARHGEF7), Polyclonal Antibody
Full Product Name
FITC-Linked Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 7 (ARHGEF7)
Product Gene Name
anti-ARHGEF7 antibody
Product Synonym Names
PAK3; BETA-PIX; COOL1; P50; P50BP; P85; P85SPR; PIXB; SH3 Domain-Containing Proline-Rich Protein; PAK-Interacting Exchange Factor Beta
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Concentration
500ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: ARHGEF7 (MBS2032443)
FITC Conjugated Antibody: ARHGEF7 (MBS2081874)
Matching Pairs
FITC Conjugated Antibody: ARHGEF7 (MBS2081874)
Immunogen: ARHGEF7 (MBS2032934)
Molecular Weight
79,696 Da
3D Structure
ModBase 3D Structure for Q9ES28
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
ARHGEF7 (Met1~Ala188)
Conjugation
FITC
Cross Reactivity
Human, Rat
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032443
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ARHGEF7 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Other Notes

Small volumes of anti-ARHGEF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF7. It may not necessarily be applicable to this product.

NCBI GI #
165377085
NCBI GeneID
54126
NCBI Accession #
NP_001106989.1
UniProt Primary Accession #
Q9ES28
UniProt Secondary Accession #
O08757; Q3UTS5; Q6XPA5; Q6ZQI5; Q8C750; Q91ZZ6; Q9ES27
UniProt Related Accession #
Q9ES28
GenBank Nucleotide #
NM_001113517.1
NCBI Official Full Name
rho guanine nucleotide exchange factor 7 isoform a
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF7)
NCBI Official Symbol
Arhgef7
NCBI Official Synonym Symbols
PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142
UniProt Protein Name
Rho guanine nucleotide exchange factor 7
UniProt Synonym Protein Names
Beta-Pix; PAK-interacting exchange factor beta; p85SPR
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
Arhgef7
UniProt Synonym Gene Names
Kiaa0142; Pak3bp
NCBI Protein Information
rho guanine nucleotide exchange factor 7

UniProt Comments for ARHGEF7

ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8|8 A1.1

Cellular Component: cell soma; cytoplasm; cytosol; focal adhesion; growth cone; lamellipodium; neuron projection; plasma membrane; protein complex

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding

Biological Process: astrocyte cell migration; focal adhesion formation; Golgi organization and biogenesis; hemopoietic progenitor cell differentiation; lamellipodium biogenesis; positive regulation of apoptosis; positive regulation of growth hormone secretion; positive regulation of GTPase activity; positive regulation of protein binding; small GTPase mediated signal transduction
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Research Articles on ARHGEF7

1. Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARHGEF7 antibody

 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with anti-ARHGEF7 antibody

 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >2 publications with ARHGEF7 and Neurobehavioral Manifestations
 Nervous System Diseases Antibodies  >2 publications with ARHGEF7 and Nervous System Diseases
 Chromosome Aberrations Antibodies  >1 publications with ARHGEF7 and Chromosome Aberrations
 Kidney Diseases Antibodies  >1 publications with ARHGEF7 and Kidney Diseases
 Hypospadias Antibodies  >1 publications with ARHGEF7 and Hypospadias
 Adenocarcinoma Antibodies  >1 publications with ARHGEF7 and Adenocarcinoma
 Carcinoma Antibodies  >1 publications with ARHGEF7 and Carcinoma
 Neoplasms Antibodies  >1 publications with ARHGEF7 and Neoplasms

Organs/Tissues associated with anti-ARHGEF7 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with ARHGEF7 and Kidney
 Embryonic Tissue Antibodies  >1 publications with ARHGEF7 and Embryonic Tissue
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