Rabbit Anti-DMTN Antibody – Cat# MBS002086

Dematin (Ab-403) (DMTN) Antibody – Rabbit

Name: DMTN Antibody; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS002086
Price: 595 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS002086

MBS002086 is an antibody targeting DMTN. Also known as Rabbit Dematin (Ab-403) Antibody. Reactive in Human, mouse. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Dematin (Ab-403) (DMTN), Antibody

Full Product Name

Rabbit Dematin (Ab-403) Antibody

Product Gene Name

anti-DMTN antibody

Host

Rabbit

Species Reactivity

Human, mouse

Form/Format

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Concentration

1 mg/ml (lot specific)

Molecular Weight

45,514 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (21911081..21940036). Location: 8p21.1

OMIM

125305

3D Structure

ModBase 3D Structure for Q08495

Applications Tested/Suitable for anti-DMTN antibody

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

Other Notes

Small volumes of anti-DMTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DMTN. It may not necessarily be applicable to this product.

NCBI GI #

166706877

NCBI GeneID

2039

NCBI Accession #

NP_001107607.1

UniProt Primary Accession #

Q08495

UniProt Secondary Accession #

Q13215; Q9BRE3; A8K0T5; B3KP70; B3KRH3; E9PEJ0

UniProt Related Accession #

Q08495

GenBank Nucleotide #

NM_001114135.2

NCBI Official Full Name

dematin isoform 1

NCBI Official Synonym Full Names

dematin actin binding protein

NCBI Official Symbol

DMTN

NCBI Official Synonym Symbols

DMT; EPB49

UniProt Protein Name

Dematin

UniProt Synonym Protein Names

Erythrocyte membrane protein band 4.9

Protein Family

Dematin

UniProt Gene Name

EPB49

UniProt Synonym Gene Names

DMT

UniProt Entry Name

DEMA_HUMAN

NCBI Protein Information

dematin; erythrocyte membrane protein band 4.9 (dematin)

NCBI Summary for DMTN

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).[supplied by OMIM, Apr 2009]

UniProt Comments for DMTN

dematin: a probable DNA binding protein, with a Myb-like DNA-binding and ELM2 domain.

Protein type: Tumor suppressor; Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: cortical cytoskeleton; perinuclear region of cytoplasm; cell projection membrane; cytoplasmic membrane-bound vesicle; plasma membrane; endomembrane system; actin filament; cytosol; actin cytoskeleton

Molecular Function: protein binding; protein self-association; spectrin binding; actin binding; receptor binding

Biological Process: regulation of cell shape; actin filament bundle formation; negative regulation of peptidyl-tyrosine phosphorylation; erythrocyte development; positive regulation of blood coagulation; actin filament capping; regulation of actin cytoskeleton organization and biogenesis; negative regulation of focal adhesion formation; negative regulation of peptidyl-serine phosphorylation; cytoskeleton organization and biogenesis; regulation of filopodium formation; protein complex assembly; actin cytoskeleton organization and biogenesis

Research Articles on DMTN

1. When unphosphorylated, dematin's two F-actin binding domains move independent of one another permitting them to bind different F-actin filaments.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-DMTN antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with DMTN and Brain
Blood Antibodies	>1 publications with DMTN and Blood