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Natriuretic Peptide Precursor A (NPPA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2090418
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MBS2090418 is an antibody targeting NPPA. Also known as Natriuretic Peptide Precursor A (NPPA) Polyclonal Antibody. Reactive in Rat, Human, Mouse. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Natriuretic Peptide Precursor A (NPPA), Polyclonal Antibody
Full Product Name
Natriuretic Peptide Precursor A (NPPA) Polyclonal Antibody
Product Gene Name
anti-NPPA antibody
Product Synonym Names
Polyclonal Antibody to Natriuretic Peptide Precursor A (NPPA); ANH; ANF; PND; NPPA; CDD-ANF; Atrial Natriuretic Factor; Atrial Natriuretic Hormone; Atriopeptin; Natriuretic Peptide Precursor A; Prepronatriodilatin; Cardiodilatin-related peptide
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat, Human, Mouse
Form/Format
Liquid
Purity/Purification
Antigen-specific affinity chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against NPPA. It has been selected for its ability to recognize NPPA in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: NPPA (MBS2090418)
Immunogen: NPPA (MBS2090438)
Matching Pairs
Unconjugated Antibody: Natriuretic Peptide Precursor A (NPPA) (MBS2090418)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
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Molecular Weight
16,556 Da
3D Structure
ModBase 3D Structure for P01161
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Rat
Immunogen
Recombinant Natriuretic Peptide Precursor A (NPPA)
Cross Reactivity
Human, Mouse, Rat
Buffer Formulation
PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-NPPA antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-NPPA antibody
Western blotting: 0.5-2ug/mL
Immunocytochemistry in formalin fixed cells: 5-20ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL
Immunohistochemistry in paraffin section: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-NPPA antibody

Western Blot: Sample: Lane1: Mouse Heart Tissue; Lane2: Rat Heart Tissue.
Rabbit Anti-NPPA Polyclonal Antibody – Cat# MBS2090418

Western Blot (WB) of anti-NPPA antibody

Western Blot: Sample: Recombinant NPPA, Rat.
Rabbit Anti-NPPA Polyclonal Antibody, Western Blot (WB) – Cat# MBS2090418

Other Notes

Small volumes of anti-NPPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NPPA. It may not necessarily be applicable to this product.

NCBI GI #
6981278
NCBI GeneID
24602
NCBI Accession #
NP_036744.1
UniProt Primary Accession #
P01161
UniProt Related Accession #
P01161
GenBank Nucleotide #
NM_012612.2
NCBI Official Full Name
natriuretic peptides A
NCBI Official Synonym Full Names
natriuretic peptide A
NCBI Official Symbol
Nppa
NCBI Official Synonym Symbols
ANF; ANP; Pnd; RATANF
UniProt Protein Name
Natriuretic peptides A
UniProt Synonym Protein Names
Prepronatriodilatin
UniProt Gene Name
Nppa
UniProt Synonym Gene Names
ANF; ANP
NCBI Protein Information
natriuretic peptides A

NCBI Summary for NPPA

peptide involved in the control of fluid volume and vascular function [RGD, Feb 2006]

UniProt Comments for NPPA

NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted; Secreted, signal peptide
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Research Articles on NPPA

1. we suggest that the order of secretagogue effect of ET family on ANP secretion was ET-1>/=ET-2>>ET-3>s6C and ET-1-induced atrial natriuretic peptide secretion negatively regulates the pressor effect of ET-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPPA antibody

 Reference Product  PubMed Publications
 Tbx5 antibody  >17 publications with NPPA and Tbx5
 Npr1 antibody  >9 publications with NPPA and Npr1
 Npr3 antibody  >5 publications with NPPA and Npr3
 Apoa1 antibody  >1 publications with NPPA and Apoa1

Pathways associated with anti-NPPA antibody

 Products by Pathway  Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Physiological Factors Pathway antibodies  Physiological Factors Pathway Diagram

Diseases associated with anti-NPPA antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >143 publications with NPPA and Heart Diseases
 Heart Failure Antibodies  >88 publications with NPPA and Heart Failure
 Hypertension Antibodies  >64 publications with NPPA and Hypertension
 Hypertrophy Antibodies  >53 publications with NPPA and Hypertrophy
 Cardiomegaly Antibodies  >38 publications with NPPA and Cardiomegaly
 Myocardial Ischemia Antibodies  >32 publications with NPPA and Myocardial Ischemia
 Kidney Diseases Antibodies  >32 publications with NPPA and Kidney Diseases
 Hypertrophy, Left Ventricular Antibodies  >21 publications with NPPA and Hypertrophy, Left Ventricular
 Cardiomyopathies Antibodies  >20 publications with NPPA and Cardiomyopathies
 Arrhythmias, Cardiac Antibodies  >20 publications with NPPA and Arrhythmias, Cardiac

Organs/Tissues associated with anti-NPPA antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >207 publications with NPPA and Heart
 Brain Antibodies  >50 publications with NPPA and Brain
 Lung Antibodies  >26 publications with NPPA and Lung
 Embryonic Tissue Antibodies  >19 publications with NPPA and Embryonic Tissue
 Dorsal Root Ganglion Antibodies  >2 publications with NPPA and Dorsal Root Ganglion
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