Heat Shock 70kDa Protein 2 (HSPA2) Antibody – Mouse Monoclonal

HSPA2: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Interacts with ZNF541. Component of the CatSper complex. Belongs to the heat shock protein 70 family.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: blood microparticle; cell surface; cytosol; extracellular exosome; male germ cell nucleus; membrane; mitochondrion; myelin sheath; nucleus; synaptonemal complex

Molecular Function: ATP binding; enzyme binding; glycolipid binding; protein binding; unfolded protein binding

Biological Process: male meiosis I; male meiotic nuclear division; negative regulation of inclusion body assembly; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle; protein refolding; response to cold; response to heat; response to unfolded protein; spermatid development; spermatogenesis