Angiotensin II Receptor 1 (AGTR1) Antibody – Rabbit Polyclonal

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: integral component of membrane; integral component of plasma membrane; intracellular; plasma membrane

Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity

Biological Process: angiotensin-activated signaling pathway; calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor signaling pathway; kidney development; low-density lipoprotein particle remodeling; phospholipase C-activating angiotensin-activated signaling pathway; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of cellular protein metabolic process; positive regulation of cholesterol esterification; positive regulation of inflammatory response; positive regulation of macrophage derived foam cell differentiation; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; positive regulation of reactive oxygen species metabolic process; regulation of blood vessel diameter; regulation of blood vessel diameter by renin-angiotensin; regulation of cell growth; regulation of cell proliferation; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; renin-angiotensin regulation of aldosterone production; Rho protein signal transduction

Disease: Hypertension, Essential; Renal Tubular Dysgenesis