Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1) Antibody – Rabbit Polyclonal

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: cell surface; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; plasma membrane

Molecular Function: carbohydrate binding; MHC class I protein binding; MHC class Ib receptor activity; protein binding; protein homodimerization activity; receptor activity

Biological Process: adaptive immune response; cell differentiation; defense response to Gram-positive bacterium; natural killer cell activation; natural killer cell mediated cytotoxicity; positive regulation of interferon-gamma production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of nitric oxide biosynthetic process; regulation of immune response; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation