Receptor Interacting Serine Threonine Kinase 2 (RIPK2) Antibody – Rabbit Polyclonal

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB.

Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle

Molecular Function: ATP binding; CARD domain binding; caspase binding; identical protein binding; LIM domain binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity

Biological Process: activation of MAPK activity; adaptive immune response; apoptosis; defense response to Gram-positive bacterium; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; JNK cascade; lipopolysaccharide-mediated signaling pathway; MAPK cascade; negative regulation of apoptosis; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis; positive regulation of cell death; positive regulation of chemokine production; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of immature T cell proliferation; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of T-helper 1 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of xenophagy; protein deubiquitination; response to exogenous dsRNA; signal transduction; T cell proliferation; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway