Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) Antibody – Rabbit Polyclonal

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family

Chromosomal Location of Human Ortholog: 9q21.33

Cellular Component: cytosol; early endosome; early endosome membrane; integral component of plasma membrane; postsynaptic density; postsynaptic membrane; receptor complex; terminal bouton

Molecular Function: ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; neurotrophin binding; protein binding; protein homodimerization activity

Biological Process: brain-derived neurotrophic factor receptor signaling pathway; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; learning; mechanoreceptor differentiation; negative regulation of anoikis; negative regulation of neuron apoptosis; neuromuscular junction development; neuron differentiation; neuron migration; neurotrophin signaling pathway; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system neuron development; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein phosphorylation; positive regulation of synaptogenesis; protein autophosphorylation; regulation of GTPase activity; regulation of protein kinase B signaling; retina development in camera-type eye; retinal rod cell development; vasculogenesis

Disease: Obesity, Hyperphagia, And Developmental Delay