Serine/Arginine Rich Splicing Factor 1 (SRSF1) Antibody – Rabbit Polyclonal

This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

SF2: a serine-arginine-rich splicing regulatory protein. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice-site-containing pre-mRNA. Extensively phosphorylated on serine residues in the serine-arginine rich region. Three splice variant isoforms have been described. ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.

Protein type: RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: catalytic step 2 spliceosome; cytoplasm; extracellular exosome; nuclear speck; nucleoplasm; nucleus

Molecular Function: DNA topoisomerase binding; mRNA binding; protein binding; protein kinase B binding; RNA binding; RS domain binding

Biological Process: alternative mRNA splicing, via spliceosome; cardiac muscle contraction; in utero embryonic development; mRNA 3'-end processing; mRNA export from nucleus; mRNA processing; mRNA splice site selection; mRNA splicing, via spliceosome; nuclear mRNA 5'-splice site recognition; oligodendrocyte differentiation; positive regulation of RNA splicing; RNA export from nucleus; termination of RNA polymerase II transcription