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Cannabinoid Receptor 1, Brain (CNR1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2094993
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MBS2094993 is an antibody targeting CNR1. Also known as Biotin-Linked Polyclonal Antibody to Cannabinoid Receptor 1, Brain (CNR1). Reactive in Rat, Human, Mouse. Host: Rabbit. More details

$235 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cannabinoid Receptor 1, Brain (CNR1), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Cannabinoid Receptor 1, Brain (CNR1)
Product Gene Name
anti-CNR1 antibody
Product Synonym Names
CANN6; CB-R; CB1; CB1A; CB1K5; CNR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat, Human, Mouse
Concentration
500ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: CNR1 (MBS2032640)
Biotin Conjugated Antibody: CNR1 (MBS2094993)
Matching Pairs
Biotin Conjugated Antibody: CNR1 (MBS2094993)
Immunogen: CNR1 (MBS2033143)
Molecular Weight
52,845 Da
3D Structure
ModBase 3D Structure for P20272
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
Biotin
Cross Reactivity
Rat
Immunogen
CNR1 (Met1~Gln117)
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CNR1 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-CNR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNR1. It may not necessarily be applicable to this product.

NCBI GI #
6978673
NCBI GeneID
25248
NCBI Accession #
NP_036916.1
UniProt Primary Accession #
P20272
UniProt Related Accession #
P20272
GenBank Nucleotide #
NM_012784.4
NCBI Official Full Name
cannabinoid receptor 1
NCBI Official Synonym Full Names
cannabinoid receptor 1
NCBI Official Symbol
Cnr1
NCBI Official Synonym Symbols
SKR6R
UniProt Protein Name
Cannabinoid receptor 1
UniProt Synonym Protein Names
Brain-type cannabinoid receptor
Protein Family
Cannabinoid receptor
UniProt Gene Name
Cnr1
UniProt Synonym Gene Names
; CB-R; CB1
NCBI Protein Information
cannabinoid receptor 1

NCBI Summary for CNR1

G-protein coupled receptor for psychoactive cannabinoids; may mediate inhibition of NO production and participate in retrograde signaling by endocannabinoids [RGD, Feb 2006]

UniProt Comments for CNR1

CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q21

Cellular Component: actin cytoskeleton; axon; growth cone; integral component of membrane; intracellular membrane-bound organelle; membrane raft; mitochondrial outer membrane; mitochondrion; plasma membrane; presynaptic membrane

Molecular Function: cannabinoid receptor activity; drug binding; protein binding

Biological Process: aging; axonal fasciculation; cannabinoid signaling pathway; G-protein coupled receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; glucose homeostasis; learning and/or memory; maternal process involved in female pregnancy; memory; negative regulation of action potential; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of fatty acid beta-oxidation; negative regulation of ion transport; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of apoptosis; positive regulation of blood pressure; positive regulation of fever; positive regulation of neuron projection development; regulation of insulin secretion; regulation of lipid metabolic process; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; response to cocaine; response to ethanol; response to lipopolysaccharide; response to morphine; response to nicotine; response to nutrient; sensory perception of pain; spermatogenesis
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Research Articles on CNR1

1. The CB1 neutral antagonist AM4113 significantly attenuated nicotine taking, motivation for nicotine, as well as cue-, priming- and stress-induced reinstatement of nicotine-seeking behavior.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNR1 antibody

 Reference Product  PubMed Publications
 Npy antibody  >9 publications with CNR1 and Npy
 Gpr55 antibody  >9 publications with CNR1 and Gpr55
 Oprm1 antibody  >6 publications with CNR1 and Oprm1
 Pomc antibody  >4 publications with CNR1 and Pomc
 Grm3 antibody  >1 publications with CNR1 and Grm3

Pathways associated with anti-CNR1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram

Diseases associated with anti-CNR1 antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >72 publications with CNR1 and Obesity
 Nervous System Diseases Antibodies  >66 publications with CNR1 and Nervous System Diseases
 Substance-Related Disorders Antibodies  >61 publications with CNR1 and Substance-Related Disorders
 Disease Models, Animal Antibodies  >51 publications with CNR1 and Disease Models, Animal
 Schizophrenia Antibodies  >47 publications with CNR1 and Schizophrenia
 Brain Diseases Antibodies  >35 publications with CNR1 and Brain Diseases
 Pain Antibodies  >35 publications with CNR1 and Pain
 Inflammation Antibodies  >25 publications with CNR1 and Inflammation
 Marijuana Abuse Antibodies  >25 publications with CNR1 and Marijuana Abuse
 Weight Gain Antibodies  >22 publications with CNR1 and Weight Gain

Organs/Tissues associated with anti-CNR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >208 publications with CNR1 and Brain
 Ovary Antibodies  >7 publications with CNR1 and Ovary
 Inner Ear Antibodies  >1 publications with CNR1 and Inner Ear
 Prostate Antibodies  >1 publications with CNR1 and Prostate
 Uncharacterized Tissue Antibodies  >1 publications with CNR1 and Uncharacterized Tissue
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