Insulin Receptor Substrate 2 (IRS2) Antibody – Rabbit Polyclonal

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytosol; plasma membrane; protein complex

Molecular Function: 1-phosphatidylinositol-3-kinase activity; 14-3-3 protein binding; insulin receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; Ras guanyl-nucleotide exchange factor activity; signal transducer activity

Biological Process: axon guidance; brain development; cell proliferation; cellular response to glucose stimulus; cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; interleukin-7-mediated signaling pathway; lipid homeostasis; mammary gland development; MAPK cascade; negative regulation of B cell apoptotic process; negative regulation of kinase activity; negative regulation of plasma membrane long-chain fatty acid transport; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; positive regulation of mesenchymal cell proliferation; positive regulation of protein kinase B signaling; regulation of lipid metabolic process; response to glucose stimulus; signal transduction

Disease: Diabetes Mellitus, Noninsulin-dependent