Ephrin Type A Receptor 4 (EPHA4) Antibody – Rabbit Polyclonal

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: axon; axon terminus; axonal growth cone; cell junction; cell surface; cytoplasm; dendrite; dendritic shaft; dendritic spine; early endosome membrane; endoplasmic reticulum; filopodium; Golgi apparatus; integral component of plasma membrane; mitochondrial outer membrane; neuromuscular junction; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: ATP binding; ephrin receptor binding; GPI-linked ephrin receptor activity; identical protein binding; kinase activity; PH domain binding; protein binding; protein kinase activity; transmembrane-ephrin receptor activity

Biological Process: adult walking behavior; cell adhesion; cellular response to amyloid-beta; corticospinal tract morphogenesis; ephrin receptor signaling pathway; glial cell migration; motor axon guidance; negative regulation of axon regeneration; negative regulation of long-term synaptic potentiation; negative regulation of neuron projection development; nephric duct morphogenesis; neuron projection fasciculation; peptidyl-tyrosine phosphorylation; positive regulation of amyloid-beta formation; positive regulation of dendrite morphogenesis; positive regulation of JUN kinase activity; positive regulation of Rho guanyl-nucleotide exchange factor activity; protein autophosphorylation; protein stabilization; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of GTPase activity; regulation of modification of synaptic structure