Tryptophan Hydroxylase 2 (TPH2) Antibody – Rabbit Polyclonal

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]

TPH2: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1.

Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: cytosol; neuron projection

Molecular Function: iron ion binding; tryptophan 5-monooxygenase activity

Biological Process: aromatic amino acid family metabolic process; cellular response to lithium ion; circadian rhythm; indolalkylamine biosynthetic process; response to activity; response to calcium ion; response to estrogen; response to glucocorticoid stimulus; response to nutrient levels; serotonin biosynthetic process

Disease: Attention Deficit-hyperactivity Disorder, Susceptibility To, 7; Major Depressive Disorder