Trichohyalin (TCHH) Antibody – Rabbit Polyclonal

The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017]

THH: Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. Belongs to the S100-fused protein family.

Protein type: Adaptor/scaffold; Calcium-binding

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cornified envelope; cytoskeleton; cytosol

Molecular Function: calcium ion binding; transition metal ion binding

Disease: Uncombable Hair Syndrome 3