Signal Transducing Adaptor Protein 1 (STAP1) Antibody – Rabbit Polyclonal

The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

STAP1: an adaptor protein which contains pleckstrin homology (PH) and Src homology 2-like (SRC) domains and a proline-rich region. Induced in activated bone marrow-derived macrophages, and by CpG, LPS, and interferon in myeloid cell lines. Induces pro-inflammatory responses and may contribute to neuronal apoptosis and degeneration. Overexpressed, it interacts with the CSFR, inhibiting its ligand-dependent phosphorylation. Its expression inhibits cellular migration and can increase cytotoxicity against 661W photoreceptor like cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: cytoplasm; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus; protein complex

Molecular Function: macrophage colony-stimulating factor receptor binding; phospholipid binding; phosphotyrosine binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: negative regulation of macrophage chemotaxis; negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of microglial cell migration; negative regulation of phosphorylation; negative regulation of ruffle assembly; positive regulation of actin cytoskeleton reorganization; positive regulation of B cell receptor signaling pathway; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of microglial cell mediated cytotoxicity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of phagocytosis, engulfment; transmembrane receptor protein tyrosine kinase signaling pathway