LIM Domain Binding Protein 1 (LDB1) Antibody – Rabbit Polyclonal

LDB1: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: cell leading edge; nuclear chromatin; nucleoplasm; nucleus; protein complex; transcription factor complex

Molecular Function: chromatin binding; enzyme binding; LIM domain binding; protein binding; protein homodimerization activity; protein self-association; transcription corepressor activity

Biological Process: anterior/posterior axis specification; cellular component assembly; cerebellar Purkinje cell differentiation; gastrulation with mouth forming second; hair follicle development; multicellular organism development; negative regulation of erythrocyte differentiation; negative regulation of transcription, DNA-dependent; neuron differentiation; positive regulation of cell adhesion; positive regulation of hemoglobin biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of focal adhesion formation; regulation of kinase activity; regulation of RNA elongation; regulation of transcription, DNA-templated; somatic stem cell maintenance; transcription from RNA polymerase II promoter; transcription, DNA-dependent; Wnt signaling pathway