Nucleotide Binding Oligomerization Domain Containing Protein 1 (NOD1) Antibody – Rabbit Polyclonal

This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

NOD1: Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytosol

Molecular Function: ATP binding; CARD domain binding; caspase activator activity; identical protein binding; peptidoglycan binding; protein binding; protein homodimerization activity

Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of MAPK activity; apoptosis; defense response; defense response to bacterium; defense response to Gram-positive bacterium; detection of bacterium; detection of biotic stimulus; inflammatory response; innate immune response; interleukin-8 biosynthetic process; JNK cascade; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of dendritic cell antigen processing and presentation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric-oxide synthase activity; positive regulation of tumor necrosis factor production; protein deubiquitination; protein oligomerization; signal transduction