Transcription Factor Dp1 (TFDP1) Antibody – Rabbit Polyclonal

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

TFDP1: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus

Molecular Function: DNA binding transcription factor activity; protein binding; protein domain specific binding; transcription coactivator activity; transcription factor binding

Biological Process: anoikis; cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epidermis development; G1/S-specific transcription in mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter