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Inhibin Beta C (INHbC) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2106935
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MBS2106935 is an antibody targeting INHbC. Also known as FITC-Linked Monoclonal Antibody to Inhibin Beta C (INHbC). Reactive in Human. Host: Mouse. More details

$255 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Inhibin Beta C (INHbC), Monoclonal Antibody
Full Product Name
FITC-Linked Monoclonal Antibody to Inhibin Beta C (INHbC)
Product Gene Name
anti-INHbC antibody
Product Synonym Names
IHBC; INH-Bc
Immunogen Sequence
Arg236~Ser 352
Clonality
Monoclonal
Isotype
IgG
Clone Number
C3
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a Mouse monoclonal antibody raised against INHbC. It has been selected for its ability to recognize INHbC in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: INHbC Clone #C3 (MBS2090653)
FITC Conjugated Antibody: INHbC Clone #C3 (MBS2106935)
Matching Pairs
FITC Conjugated Antibody: INHbC Clone #C3 (MBS2106935)
Immunogen: INHbC (MBS2011278)
OMIM
601233
3D Structure
ModBase 3D Structure for P55103
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
FITC
Cross Reactivity
Human
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-INHbC antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Other Notes

Small volumes of anti-INHbC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for INHbC. It may not necessarily be applicable to this product.

NCBI GI #
5031795
NCBI GeneID
3626
NCBI Accession #
NP_005529.1
UniProt Primary Accession #
P55103
UniProt Related Accession #
P55103
GenBank Nucleotide #
NM_005538.4
NCBI Official Full Name
inhibin beta C chain preproprotein
NCBI Official Synonym Full Names
inhibin subunit beta C
NCBI Official Symbol
INHBC
NCBI Official Synonym Symbols
IHBC
UniProt Protein Name
Inhibin beta C chain
UniProt Synonym Protein Names
Activin beta-C chain
Protein Family
Inhibin
UniProt Gene Name
INHBC
UniProt Entry Name
INHBC_HUMAN
NCBI Protein Information
inhibin beta C chain

NCBI Summary for INHbC

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
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UniProt Comments for INHbC

INHBC: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; regulation of MAPKKK cascade; cell development; growth
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Research Articles on INHbC

1. Study shows an up-regulation of activin-C in aggressive prostate cancer only, suggesting that activin-C may play a role in the advanced stages of the disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-INHbC antibody

 Reference Product  PubMed Publications
 INHBE antibody  >6 publications with INHbC and INHBE
 INHBB antibody  >2 publications with INHbC and INHBB
 INHA antibody  >1 publications with INHbC and INHA
 ACVR1B antibody  >1 publications with INHbC and ACVR1B
 INHBA antibody  >1 publications with INHbC and INHBA

Pathways associated with anti-INHbC antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Biosynthesis Pathway antibodies  Peptide Hormone Biosynthesis Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-INHbC antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with INHbC and Neoplasms
 Carcinoma Antibodies  >5 publications with INHbC and Carcinoma
 Liver Diseases Antibodies  >2 publications with INHbC and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >2 publications with INHbC and Carcinoma, Squamous Cell
 Liver Cirrhosis Antibodies  >1 publications with INHbC and Liver Cirrhosis
 Fibrosis Antibodies  >1 publications with INHbC and Fibrosis
 Liver Cirrhosis, Experimental Antibodies  >1 publications with INHbC and Liver Cirrhosis, Experimental
 Hypertrophy Antibodies  >1 publications with INHbC and Hypertrophy
 Lung Neoplasms Antibodies  >1 publications with INHbC and Lung Neoplasms
 Inflammation Antibodies  >1 publications with INHbC and Inflammation

Organs/Tissues associated with anti-INHbC antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with INHbC and Liver
 Ovary Antibodies  >3 publications with INHbC and Ovary
 Testis Antibodies  >2 publications with INHbC and Testis
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