CD49b Antibody – Rat Monoclonal

ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion

Cellular Component: cell surface; focal adhesion; cell projection; membrane; axon; perinuclear region of cytoplasm; plasma membrane; integral to membrane; nerve terminal; nucleus; integrin complex; external side of plasma membrane

Molecular Function: collagen binding; integrin binding; protein heterodimerization activity; metal ion binding; laminin binding; protein complex binding

Biological Process: focal adhesion formation; positive regulation of positive chemotaxis; positive regulation of cell adhesion; positive regulation of translation; positive regulation of smooth muscle cell proliferation; positive regulation of leukocyte migration; cell-matrix adhesion; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of cell projection organization and biogenesis; positive regulation of smooth muscle cell migration; establishment of protein localization; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; substrate-bound cell migration; integrin-mediated signaling pathway; skin morphogenesis; hypotonic response; cell-substrate adhesion; detection of mechanical stimulus involved in sensory perception of pain; cell adhesion mediated by integrin; positive regulation of phagocytosis, engulfment; positive regulation of transmission of nerve impulse; positive regulation of inflammatory response