Rat Anti-CD79b Monoclonal Antibody – Cat# MBS210874

Staining of rat peripheral blood lymphocytes with Rat anti Mouse CD79b:FITC after permeabilisation with Leucoperm

CD79b Antibody – Rat Monoclonal

Name: CD79b Antibody; Monoclonal; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS210874
Price: 510 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS210874

Rat anti Mouse CD79b antibody, clone AT107-2 recognizes a cytoplasmic region of mouse and human CD79b, a cell surface antigen expressed by B lymphocytes. The CD79b molecule (also known as Ig beta and B29) associates with CD79a to form a heterodimer that is… More details

$510 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD79b, Monoclonal Antibody

Full Product Name

RAT ANTI MOUSE CD79b:FITC

Product Gene Name

anti-CD79b antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

AT107-2

Host

Rat

Form/Format

FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

Concentration

IgG concentration 0.1 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

25,726 Da

3D Structure

ModBase 3D Structure for P15530

Perservative Stabilisers

0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen

Peptide containing 20 amino acid residues from mouse CD79b conjugated to Keyhole Limpet Hemocyanin (KLH).
Fusion Partners||Spleen cells from immunised rat were fused with cells of the mouse NS-1 myeloma cell line.
Buffer Solution||Phosphate buffered saline

Target Species

Mouse

Applications Tested/Suitable for anti-CD79b antibody

Flow cytometry (FC/FACS)*

Application Notes for anti-CD79b antibody

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/5; Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.

Other Notes

Small volumes of anti-CD79b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD79b purchase

MBS210874 is an antibody targeting CD79b. Also known as RAT ANTI MOUSE CD79b:FITC. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD79b. It may not necessarily be applicable to this product.

NCBI GI #

6680375

NCBI GeneID

15985

NCBI Accession #

NP_032365.1

UniProt Primary Accession #

P15530

UniProt Secondary Accession #

Q4FJP4

UniProt Related Accession #

P15530

GenBank Nucleotide #

NM_008339.2

NCBI Official Full Name

B-cell antigen receptor complex-associated protein beta chain

NCBI Official Synonym Full Names

CD79B antigen

NCBI Official Symbol

Cd79b

NCBI Official Synonym Symbols

B29; Igb; Igbeta; Ig-beta

UniProt Protein Name

B-cell antigen receptor complex-associated protein beta chain

UniProt Synonym Protein Names

B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b

Protein Family

B-cell antigen receptor complex-associated protein

UniProt Gene Name

Cd79b

UniProt Synonym Gene Names

Igb

UniProt Entry Name

CD79B_MOUSE

NCBI Protein Information

B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; immunoglobulin-associated beta

UniProt Comments for CD79b

Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; integral to membrane; plasma membrane; B cell receptor complex; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: B cell receptor signaling pathway; cell surface receptor linked signal transduction; immune system process

Research Articles on CD79b

1. Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD79b antibody

Reference Product	PubMed Publications
Cd79a antibody	>616 publications with CD79b and Cd79a
Cd19 antibody	>107 publications with CD79b and Cd19
Lyn antibody	>25 publications with CD79b and Lyn
Blnk antibody	>12 publications with CD79b and Blnk
Btk antibody	>10 publications with CD79b and Btk
Blk antibody	>4 publications with CD79b and Blk
Vav1 antibody	>3 publications with CD79b and Vav1
Plcg2 antibody	>1 publications with CD79b and Plcg2

Pathways associated with anti-CD79b antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Signaling By The B Cell Receptor (BCR) Pathway antibodies	Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with anti-CD79b antibody

Disease Name	Pubmed Publications
Lymphoma, Large B-Cell, Diffuse Antibodies	>80 publications with CD79b and Lymphoma, Large B-Cell, Diffuse
Inflammation Antibodies	>18 publications with CD79b and Inflammation
Liver Diseases Antibodies	>18 publications with CD79b and Liver Diseases
Hyperplasia Antibodies	>16 publications with CD79b and Hyperplasia
Lung Diseases Antibodies	>11 publications with CD79b and Lung Diseases
Disease Models, Animal Antibodies	>10 publications with CD79b and Disease Models, Animal
Necrosis Antibodies	>10 publications with CD79b and Necrosis
Liver Neoplasms Antibodies	>9 publications with CD79b and Liver Neoplasms
Anemia Antibodies	>7 publications with CD79b and Anemia
Weight Loss Antibodies	>5 publications with CD79b and Weight Loss

Organs/Tissues associated with anti-CD79b antibody

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>112 publications with CD79b and Bone Marrow
Lymph Node Antibodies	>91 publications with CD79b and Lymph Node
Spleen Antibodies	>54 publications with CD79b and Spleen
Liver Antibodies	>38 publications with CD79b and Liver
Intestine Antibodies	>23 publications with CD79b and Intestine
Lung Antibodies	>19 publications with CD79b and Lung
Thymus Antibodies	>19 publications with CD79b and Thymus
Pancreas Antibodies	>7 publications with CD79b and Pancreas
Salivary Gland Antibodies	>6 publications with CD79b and Salivary Gland