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Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2108978
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MBS2108978 is an antibody targeting KLRK1. Also known as Botin-Linked Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1). Reactive in Human, Rat. Host: Mouse. More details

$230 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1), Monoclonal Antibody
Full Product Name
Botin-Linked Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily K, Member 1 (KLRK1)
Product Gene Name
anti-KLRK1 antibody
Product Synonym Names
CD314; KLR-K1; KLR; NKG2-D; NKG2-D Type II Integral Membrane Protein; NK cell receptor D; NKG2-D-activating NK receptor
Immunogen Sequence
Thr92~Val2 16
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
C1
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a mouse monoclonal antibody raised against KLRK1. It has been selected for its ability to recognize KLRK1 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Biotin Conjugated Antibody: KLRK1 Clone #C1 (MBS2108978)
Immunogen: KLRK1 (MBS2033443)
Matching Pairs
Unconjugated Antibody: KLRK1 Clone #C1 (MBS2111245)
Biotin Conjugated Antibody: KLRK1 Clone #C1 (MBS2108978)
OMIM
611817
3D Structure
ModBase 3D Structure for P26718
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
Biotin
Cross Reactivity
Human
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-KLRK1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Other Notes

Small volumes of anti-KLRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRK1. It may not necessarily be applicable to this product.

NCBI GI #
315221164
NCBI GeneID
100528032
NCBI Accession #
NP_001186734.1
UniProt Primary Accession #
P26718
UniProt Related Accession #
P26718
GenBank Nucleotide #
NM_001199805.1
NCBI Official Full Name
NKG2-D type II integral membrane protein
NCBI Official Synonym Full Names
KLRC4-KLRK1 readthrough
NCBI Official Symbol
KLRC4-KLRK1
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor
Protein Family
NKG2-D type II integral membrane protein
UniProt Gene Name
KLRK1
UniProt Synonym Gene Names
D12S2489E; NKG2D
UniProt Entry Name
NKG2D_HUMAN
NCBI Protein Information
NKG2-D type II integral membrane protein

NCBI Summary for KLRK1

This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]
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UniProt Comments for KLRK1

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KLRK1 antibody

 Products by Pathway  Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Organs/Tissues associated with anti-KLRK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with KLRK1 and Blood
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