Mouse Anti-LMNB1 Monoclonal Antibody – Cat# MBS2111316

Western Blot: Sample: Lane1: Human Lung lysate; Lane2: Porcine Cerebrum

Lamin B1 (LMNB1) Antibody – Mouse Monoclonal

Name: LMNB1 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS2111316
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2111316

MBS2111316 is an antibody targeting LMNB1. Also known as Monoclonal Antibody to Lamin B1 (LMNB1). Reactive in Human, Guinea pig, Ratbbit, Dog, Bovine, Goat, Sheep. Host: Mouse. More details

$235 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Lamin B1 (LMNB1), Monoclonal Antibody

Full Product Name

Monoclonal Antibody to Lamin B1 (LMNB1)

Product Gene Name

anti-LMNB1 antibody

Clonality

Monoclonal

Host

Mouse

Species Reactivity

Human, Guinea pig, Ratbbit, Dog, Bovine, Goat, Sheep

Form/Format

Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Purity/Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Concentration

1mg/mL (lot specific)

Specificity

The antibody is a mouse monoclonal antibody raised against LMNB1. It has been selected for its ability to recognize LMNB1 in immunohistochemical staining and western blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

OMIM

gene 169500

3D Structure

ModBase 3D Structure for P20700

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Conjugation

None

Cross Reactivity

Human

Product Categories/Family for anti-LMNB1 antibody

Metabolic pathway

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-LMNB1 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-LMNB1 antibody

WB: 0.2-2ug/mL; 1:500-5000
IHC: 5-20ug/mL; 1:50-200
ICC: 5-20ug/mL; 1:50-200

Other Notes

Small volumes of anti-LMNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.

NCBI GI #

125953

NCBI GeneID

4001

NCBI Accession #

P20700.2

UniProt Primary Accession #

P20700

UniProt Related Accession #

P20700

NCBI Official Full Name

Lamin-B1

NCBI Official Synonym Full Names

lamin B1

NCBI Official Symbol

LMNB1

NCBI Official Synonym Symbols

LMN; ADLD; LMN2; LMNB

UniProt Protein Name

Lamin-B1

Protein Family

Lamin

UniProt Gene Name

LMNB1

UniProt Synonym Gene Names

LMN2; LMNB

UniProt Entry Name

LMNB1_HUMAN

NCBI Protein Information

lamin-B1

NCBI Summary for LMNB1

This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

UniProt Comments for LMNB1

Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope

Molecular Function: phospholipase binding; structural molecule activity

Biological Process: apoptosis; cell structure disassembly during apoptosis

Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant

Research Articles on LMNB1

1. Results show that HECW2 interacts with lamin B1 mediating its ubiquitination and proteasomal degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LMNB1 antibody

Reference Product	PubMed Publications
LMNA antibody	>15 publications with LMNB1 and LMNA
LMNB2 antibody	>13 publications with LMNB1 and LMNB2
BRCA1 antibody	>1 publications with LMNB1 and BRCA1
CDK1 antibody	>1 publications with LMNB1 and CDK1

Pathways associated with anti-LMNB1 antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Breakdown Of The Nuclear Lamina Pathway antibodies	Breakdown Of The Nuclear Lamina Pathway Diagram
Caspase Cascade In Apoptosis Pathway antibodies	Caspase Cascade In Apoptosis Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
DNA Damage/Telomere Stress Induced Senescence Pathway antibodies	DNA Damage/Telomere Stress Induced Senescence Pathway Diagram

Diseases associated with anti-LMNB1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>21 publications with LMNB1 and Nervous System Diseases
Carcinoma Antibodies	>6 publications with LMNB1 and Carcinoma
Adenocarcinoma Antibodies	>5 publications with LMNB1 and Adenocarcinoma
Liver Diseases Antibodies	>4 publications with LMNB1 and Liver Diseases
Pelizaeus-Merzbacher Disease Antibodies	>4 publications with LMNB1 and Pelizaeus-Merzbacher Disease
Carcinoma, Hepatocellular Antibodies	>3 publications with LMNB1 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>3 publications with LMNB1 and Liver Neoplasms
Disease Models, Animal Antibodies	>2 publications with LMNB1 and Disease Models, Animal
Abnormalities, Multiple Antibodies	>2 publications with LMNB1 and Abnormalities, Multiple
Pancreatic Neoplasms Antibodies	>1 publications with LMNB1 and Pancreatic Neoplasms

Organs/Tissues associated with anti-LMNB1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>13 publications with LMNB1 and Brain
Blood Antibodies	>8 publications with LMNB1 and Blood
Skin Antibodies	>6 publications with LMNB1 and Skin
Muscle Antibodies	>5 publications with LMNB1 and Muscle
Liver Antibodies	>4 publications with LMNB1 and Liver
Bone Antibodies	>4 publications with LMNB1 and Bone
Kidney Antibodies	>1 publications with LMNB1 and Kidney
Lung Antibodies	>1 publications with LMNB1 and Lung
Intestine Antibodies	>1 publications with LMNB1 and Intestine
Connective Tissue Antibodies	>1 publications with LMNB1 and Connective Tissue