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Chemokine (C-X-C Motif) Ligand 3 (CXCL3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2115927
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MBS2115927 is an antibody targeting CXCL3. Also known as HRP-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 3 (CXCL3). Reactive in Rat. Host: Rabbit. More details

$255 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Chemokine (C-X-C Motif) Ligand 3 (CXCL3), Polyclonal Antibody
Full Product Name
HRP-Linked Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 3 (CXCL3)
Product Gene Name
anti-CXCL3 antibody
Product Synonym Names
GROg; SCYB3; GRO3; GRO-G; MIP2-B; MIP2b; CINC2b; CINC2b; Growth Regulated Oncogene Gamma; Macrophage inflammatory protein 2-beta
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against CXCL3. It has been selected for its ability to recognize CXCL3 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: CXCL3 (MBS2112125)
HRP Conjugated Antibody: CXCL3 (MBS2115927)
OMIM
139111
3D Structure
ModBase 3D Structure for P19876
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Cross Reactivity
Rat
Conjugation
HRP

Product Categories/Family for anti-CXCL3 antibody

Cytokine; Tumor Immunity; Infection Immunity
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CXCL3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Other Notes

Small volumes of anti-CXCL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL3. It may not necessarily be applicable to this product.

NCBI GI #
54144650
NCBI GeneID
2921
UniProt Primary Accession #
P19876
UniProt Related Accession #
P19876
GenBank Nucleotide #
NP_002081.2
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
C-X-C motif chemokine ligand 3
NCBI Official Symbol
CXCL3
NCBI Official Synonym Symbols
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL3
UniProt Synonym Gene Names
GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta
UniProt Entry Name
CXCL3_HUMAN
NCBI Protein Information
C-X-C motif chemokine 3

NCBI Summary for CXCL3

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
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UniProt Comments for CXCL3

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; immune response; inflammatory response; regulation of cell proliferation
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Research Articles on CXCL3

1. Study demonstrated that CXCL3 is not only considerably upregulated in colon cancer (CC) tumor tissue but also has potential diagnostic value in patients with CC. Survival analysis suggested that CXCL3 may serve as a potential prognostic biomarker in CC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCL3 antibody

 Reference Product  PubMed Publications
 CXCL2 antibody  >100 publications with CXCL3 and CXCL2
 CXCL1 antibody  >100 publications with CXCL3 and CXCL1
 CCL20 antibody  >41 publications with CXCL3 and CCL20
 CCL5 antibody  >26 publications with CXCL3 and CCL5
 CXCR2 antibody  >12 publications with CXCL3 and CXCR2
 CXCR1 antibody  >8 publications with CXCL3 and CXCR1
 CXCL16 antibody  >6 publications with CXCL3 and CXCL16
 CCL19 antibody  >6 publications with CXCL3 and CCL19
 CCR1 antibody  >3 publications with CXCL3 and CCR1
 CCL16 antibody  >1 publications with CXCL3 and CCL16

Pathways associated with anti-CXCL3 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-CXCL3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >73 publications with CXCL3 and Inflammation
 Necrosis Antibodies  >35 publications with CXCL3 and Necrosis
 Respiratory Tract Diseases Antibodies  >13 publications with CXCL3 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >13 publications with CXCL3 and Lung Diseases
 Immune System Diseases Antibodies  >11 publications with CXCL3 and Immune System Diseases
 Skin Diseases Antibodies  >9 publications with CXCL3 and Skin Diseases
 Disease Models, Animal Antibodies  >7 publications with CXCL3 and Disease Models, Animal
 Death Antibodies  >7 publications with CXCL3 and Death
 Fibrosis Antibodies  >6 publications with CXCL3 and Fibrosis
 Neoplasms, Experimental Antibodies  >4 publications with CXCL3 and Neoplasms, Experimental

Organs/Tissues associated with anti-CXCL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >64 publications with CXCL3 and Blood
 Lung Antibodies  >18 publications with CXCL3 and Lung
 Intestine Antibodies  >11 publications with CXCL3 and Intestine
 Brain Antibodies  >8 publications with CXCL3 and Brain
 Embryonic Tissue Antibodies  >4 publications with CXCL3 and Embryonic Tissue
 Liver Antibodies  >4 publications with CXCL3 and Liver
 Uterus Antibodies  >2 publications with CXCL3 and Uterus
 Pancreas Antibodies  >1 publications with CXCL3 and Pancreas
 Bladder Antibodies  >1 publications with CXCL3 and Bladder
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