Rat Anti-EDN2 Monoclonal Antibody – Cat# MBS211599

Endothelin (EDN2) Antibody – Rat Monoclonal

Name: EDN2 Antibody; Monoclonal; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS211599
Price: 420 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS211599

Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a… More details

$420 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ENDOTHELIN (EDN2), Monoclonal Antibody

Full Product Name

RAT ANTI HUMAN ENDOTHELIN

Product Gene Name

anti-EDN2 antibody

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

3G10

Host

Rat

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0 mg/ml (lot specific)

Specificity

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

19,960 Da

OMIM

131241

Perservative Stabilisers

0.09% Sodium Azide (NaN3)
Preparation||Purified IgG prepared by affinity chromatography on Protein G

Immunogen

Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.
Buffer Solution||Phosphate buffered saline

Target Species

Human

Applications Tested/Suitable for anti-EDN2 antibody

Immunohistology Frozen*, IRMA (IR)

Application Notes for anti-EDN2 antibody

Immunohistology: Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.
Immunohistology - Frozen: Application Note: Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.

Other Notes

Small volumes of anti-EDN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDN2 purchase

MBS211599 is an antibody targeting EDN2. Also known as RAT ANTI HUMAN ENDOTHELIN. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for EDN2. It may not necessarily be applicable to this product.

NCBI GI #

4503463

NCBI GeneID

1907

NCBI Accession #

NP_001947.1

UniProt Secondary Accession #

Q5T1R3

UniProt Related Accession #

P20800

GenBank Nucleotide #

NM_001956.4

NCBI Official Full Name

endothelin-2 isoform 1 preproprotein

NCBI Official Synonym Full Names

endothelin 2

NCBI Official Symbol

EDN2

NCBI Official Synonym Symbols

ET2; ET-2; PPET2

UniProt Protein Name

Endothelin-2

UniProt Synonym Protein Names

Preproendothelin-2; PPET2

Protein Family

Endothelin

UniProt Gene Name

EDN2

UniProt Synonym Gene Names

ET-2; PPET2

UniProt Entry Name

EDN2_HUMAN

NCBI Protein Information

endothelin-2; preproendothelin 2

NCBI Summary for EDN2

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

UniProt Comments for EDN2

EDN2: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: vasoconstriction; neutrophil chemotaxis; inositol phosphate-mediated signaling; regulation of systemic arterial blood pressure by endothelin; positive regulation of the force of heart contraction by chemical signal; cytokine and chemokine mediated signaling pathway; calcium-mediated signaling; positive regulation of leukocyte chemotaxis; positive regulation of heart rate; thermoregulation; prostaglandin biosynthetic process; vein smooth muscle contraction; hormonal regulation of the force of heart contraction; macrophage chemotaxis; elevation of cytosolic calcium ion concentration; macrophage activation; cell surface receptor linked signal transduction; regulation of vasoconstriction; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; alveolus development; artery smooth muscle contraction

Research Articles on EDN2

1. Overexpression of Edn2 in the mouse retina causes an excess of tip cells and inhibits vascular growth. Overexpression of Edn2 in the brain and skin had no effect, but vascular development was inhibited in midgestation mouse embryos.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EDN2 antibody

Reference Product	PubMed Publications
EDN1 antibody	>15 publications with EDN2 and EDN1
EDNRB antibody	>13 publications with EDN2 and EDNRB
EDN3 antibody	>12 publications with EDN2 and EDN3
EDNRA antibody	>12 publications with EDN2 and EDNRA

Pathways associated with anti-EDN2 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Endothelins Pathway antibodies	Endothelins Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-EDN2 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>5 publications with EDN2 and Disease Models, Animal
Inflammation Antibodies	>4 publications with EDN2 and Inflammation
Necrosis Antibodies	>3 publications with EDN2 and Necrosis
Heart Diseases Antibodies	>2 publications with EDN2 and Heart Diseases
Hypertension Antibodies	>2 publications with EDN2 and Hypertension
Breast Neoplasms Antibodies	>1 publications with EDN2 and Breast Neoplasms
Lung Diseases Antibodies	>1 publications with EDN2 and Lung Diseases
Brain Diseases Antibodies	>1 publications with EDN2 and Brain Diseases
Cardiomyopathies Antibodies	>1 publications with EDN2 and Cardiomyopathies

Organs/Tissues associated with anti-EDN2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with EDN2 and Lung
Heart Antibodies	>2 publications with EDN2 and Heart
Mammary Gland Antibodies	>1 publications with EDN2 and Mammary Gland
Kidney Antibodies	>1 publications with EDN2 and Kidney