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Coenzyme A Synthase (COASY) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2118903
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MBS2118903 is an antibody targeting COASY. Also known as PE-Linked Polyclonal Antibody to Coenzyme A Synthase (COASY). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$340 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Coenzyme A Synthase (COASY), Polyclonal Antibody
Full Product Name
PE-Linked Polyclonal Antibody to Coenzyme A Synthase (COASY)
Product Gene Name
anti-COASY antibody
Product Synonym Names
NBP; PPAT; DPCK; UKR1; pOV-2; DPCOAK; Phosphopantetheine adenylyltransferase; Dephospho-CoA pyrophosphorylase; Dephospho-CoA kinase; Dephosphocoenzyme A kinase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
>=100ug/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against COASY. It has been selected for its ability to recognize COASY in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: COASY (MBS2112322)
PE Conjugated Antibody: COASY (MBS2118903)
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Cross Reactivity
Mouse
Conjugation
PE

Product Categories/Family for anti-COASY antibody

Enzyme & Kinase
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-COASY antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Other Notes

Small volumes of anti-COASY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COASY. It may not necessarily be applicable to this product.

NCBI GI #
45501329
NCBI GeneID
80347
UniProt Related Accession #
Q13057
NCBI Official Full Name
Coenzyme A synthase
NCBI Official Synonym Full Names
Coenzyme A synthase
NCBI Official Symbol
COASY
NCBI Official Synonym Symbols
NBP; DPCK; PPAT; UKR1; NBIA6; PCH12; pOV-2
Protein Family
Bifunctional coenzyme A synthase
NCBI Protein Information
bifunctional coenzyme A synthase

NCBI Summary for COASY

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
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Research Articles on COASY

1. Loss of function variants in COASY are associated with lethal pontocerebellar hypoplasia and arthrogryposis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-COASY antibody

 Products by Pathway  Pathway Diagram
 Coenzyme A Biosynthesis Pathway antibodies  Coenzyme A Biosynthesis Pathway Diagram
 Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies  Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
 Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies  Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram

Diseases associated with anti-COASY antibody

 Disease Name  Pubmed Publications
 Cognition Disorders Antibodies  >2 publications with COASY and Cognition Disorders
 Atrophy Antibodies  >1 publications with COASY and Atrophy

Organs/Tissues associated with anti-COASY antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with COASY and Brain
 Ganglia Antibodies  >3 publications with COASY and Ganglia
 Nerve Antibodies  >1 publications with COASY and Nerve
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