Pi-3 KINASE P85 SUBUNIT BETA (PIK3R2) Antibody – Mouse Monoclonal

PIK3R2: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Kinase, lipid

Cellular Component: intracellular; phosphoinositide 3-kinase complex; nucleus

Molecular Function: protein binding; protein heterodimerization activity; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity; receptor tyrosine kinase binding; transcription factor binding; protein phosphatase binding

Biological Process: phosphoinositide 3-kinase cascade; protein transport; cellular response to insulin stimulus; regulation of phosphorylation; transport; insulin receptor signaling pathway; positive regulation of transcription factor import into nucleus; cell glucose homeostasis; regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; signal transduction