N-Cadherin (NCAD) Antibody – Rabbit Polyclonal

CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: focal adhesion; protein complex; basolateral plasma membrane; T-tubule; integral to membrane; intercellular junction; catenin complex; fascia adherens; cell-cell adherens junction; adherens junction; membrane; lamellipodium; apical plasma membrane; plasma membrane; synapse

Molecular Function: protein binding; enzyme binding; gamma-catenin binding; beta-catenin binding; protein complex binding; calcium ion binding; nitric-oxide synthase binding; protein phosphatase binding; protein kinase binding; alpha-catenin binding

Biological Process: cell migration; regulation of myelination; protein heterooligomerization; regulation of axonogenesis; heterophilic cell adhesion; cell-cell adhesion; synaptogenesis; glial cell differentiation; regulation of protein localization; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; regulation of Rho protein signal transduction; striated muscle cell differentiation; blood vessel morphogenesis; cell adhesion; homophilic cell adhesion