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CD11a Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212117

Rat anti Mouse CD11a antibody, clone I21/7 recognizes murine CD11a, a ~170-180kDa type I membrane glycoprotein, also known as the integrin alpha L subunit. CD11a is a member of the intergrin family of adhesion molecules. CD11a is expressed on all leucocytes… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD11a, Monoclonal Antibody
Full Product Name
RAT ANTI MOUSE CD11a
Product Gene Name
anti-CD11a antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
I21/7
Host
Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
128,328 Da
3D Structure
ModBase 3D Structure for P24063
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen
Whole BW5147 cells.
Buffer Solution||Phosphate buffered saline
Target Species
Mouse
Applications Tested/Suitable for anti-CD11a antibody
Flow cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD11a antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.

Testing Data of anti-CD11a antibody

Staining of mouse spleen cells with Rat anti Mouse CD11a (MBS211199)
Rat Anti-CD11a Monoclonal Antibody – Cat# MBS212117

Testing Data of anti-CD11a antibody

Staining of mouse spleen cells with Rat anti Mouse CD11a:FITC (MBS210671)
Rat Anti-CD11a Monoclonal Antibody, Testing Data – Cat# MBS212117

Other Notes

Small volumes of anti-CD11a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD11a purchase

MBS212117 is an antibody targeting CD11a. Also known as RAT ANTI MOUSE CD11a. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD11a. It may not necessarily be applicable to this product.

NCBI GI #
341940846
NCBI GeneID
16408
NCBI Accession #
P24063.2
UniProt Primary Accession #
P24063
UniProt Related Accession #
P24063
NCBI Official Full Name
Integrin alpha-L
NCBI Official Synonym Full Names
integrin alpha L
NCBI Official Symbol
Itgal
NCBI Official Synonym Symbols
Cd11a; LFA-1; Ly-15; Ly-21; (p180); LFA-1A
UniProt Protein Name
Integrin alpha-L
UniProt Synonym Protein Names
CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; Lymphocyte antigen 15; Ly-15; CD_antigen: CD11a
Protein Family
Integrin
UniProt Gene Name
Itgal
UniProt Synonym Gene Names
Lfa-1; Ly-15; LFA-1A; Ly-15
UniProt Entry Name
ITAL_MOUSE
NCBI Protein Information
integrin alpha-L; CD11 antigen-like family member A; alpha L integrin; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide

UniProt Comments for CD11a

ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral; Cell surface

Cellular Component: cell surface; membrane; integral to membrane; immunological synapse; intercellular junction; integrin complex; external side of plasma membrane

Molecular Function: protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity

Biological Process: integrin-mediated signaling pathway; cell-matrix adhesion; activated T cell proliferation; positive regulation of calcium-mediated signaling; signal transduction; receptor clustering; heterophilic cell adhesion; leukocyte adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; regulation of cell-cell adhesion; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of cell-cell adhesion; positive regulation of T cell proliferation; cell adhesion
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Research Articles on CD11a

1. competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD11a antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Organs/Tissues associated with anti-CD11a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1564 publications with CD11a and Blood
 Bone Antibodies  >193 publications with CD11a and Bone
 Bone Marrow Antibodies  >183 publications with CD11a and Bone Marrow
 Lung Antibodies  >117 publications with CD11a and Lung
 Skin Antibodies  >104 publications with CD11a and Skin
 Spleen Antibodies  >76 publications with CD11a and Spleen
 Brain Antibodies  >50 publications with CD11a and Brain
 Liver Antibodies  >48 publications with CD11a and Liver
 Embryonic Tissue Antibodies  >47 publications with CD11a and Embryonic Tissue
 Thymus Antibodies  >35 publications with CD11a and Thymus
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