Mouse Anti-B2M Monoclonal Antibody – Cat# MBS212290

BETA 2 Microglobulin (B2M) Antibody – Mouse Monoclonal

Name: B2M Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS212290
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212290

Mouse anti Rat beta 2 Microglobulin antibody, clone TLD-3H12B recognizes native beta 2 microglobulin which is a component of MHC class I molecules, which are present on all nucleated cells. Levels of beta 2 microglobulin can be used to assess renal function… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BETA 2 MICROGLOBULIN (B2m), Monoclonal Antibody

Full Product Name

MOUSE ANTI RAT BETA 2 MICROGLOBULIN

Product Gene Name

anti-B2m antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

TLD-3H12B

Host

Mouse

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

13,720 Da

3D Structure

ModBase 3D Structure for P07151

Perservative Stabilisers

0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G

Immunogen

Rat microglial cells
Fusion Partners||Spleen cells from immunised BALB/c mice were fused with cells of the mouse MOM myeloma cell line.
Buffer Solution||Phosphate buffered saline

Target Species

Rat

Applications Tested/Suitable for anti-B2m antibody

Immunohistology Frozen, Flow cytometry (FC/FACS), Western Blot (WB)

Application Notes for anti-B2m antibody

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/20

Other Notes

Small volumes of anti-B2m antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for B2m purchase

MBS212290 is an antibody targeting B2m. Also known as MOUSE ANTI RAT BETA 2 MICROGLOBULIN. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for B2m. It may not necessarily be applicable to this product.

NCBI GI #

7549746

NCBI GeneID

24223

NCBI Accession #

NP_036644.1

UniProt Primary Accession #

P07151

UniProt Related Accession #

P07151

GenBank Nucleotide #

NM_012512.2

NCBI Official Full Name

beta-2-microglobulin

NCBI Official Synonym Full Names

beta-2 microglobulin

NCBI Official Symbol

B2m

UniProt Protein Name

Beta-2-microglobulin

Protein Family

Beta-2-microglobulin

UniProt Gene Name

B2m

UniProt Entry Name

B2MG_RAT

NCBI Protein Information

beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA)

NCBI Summary for B2m

mouse homolog plays a role in the assembly and surface expression of MHC class I molecules [RGD, Feb 2006]

UniProt Comments for B2m

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: Golgi apparatus; extracellular space; focal adhesion; membrane; cytoplasm; plasma membrane; MHC class I protein complex; external side of plasma membrane

Molecular Function: identical protein binding

Biological Process: response to drug; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; positive regulation of T cell mediated cytotoxicity; response to molecule of bacterial origin; T cell differentiation in the thymus; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Research Articles on B2m

1. All previously described disease manifestations in HLA-B27/Hubeta(2)m-transgenic rats arise in the absence of any functional CD8+ T cells. It seems unlikely that classic T cell recognition of HLA-B27 is of primary importance in this animal model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-B2m antibody

Reference Product	PubMed Publications
Cst3 antibody	>6 publications with B2m and Cst3
Hfe antibody	>3 publications with B2m and Hfe
Fcgrt antibody	>3 publications with B2m and Fcgrt
Rps29 antibody	>2 publications with B2m and Rps29
App antibody	>1 publications with B2m and App

Pathways associated with anti-B2m antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Amyloids Pathway antibodies	Amyloids Pathway Diagram
Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies	Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with anti-B2m antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>82 publications with B2m and Cardiovascular Diseases
Kidney Diseases Antibodies	>69 publications with B2m and Kidney Diseases
Inflammation Antibodies	>38 publications with B2m and Inflammation
Renal Insufficiency Antibodies	>28 publications with B2m and Renal Insufficiency
Disease Models, Animal Antibodies	>28 publications with B2m and Disease Models, Animal
Proteinuria Antibodies	>25 publications with B2m and Proteinuria
Liver Diseases Antibodies	>21 publications with B2m and Liver Diseases
Necrosis Antibodies	>20 publications with B2m and Necrosis
Autoimmune Diseases Antibodies	>19 publications with B2m and Autoimmune Diseases
Adenocarcinoma Antibodies	>19 publications with B2m and Adenocarcinoma

Organs/Tissues associated with anti-B2m antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>108 publications with B2m and Kidney
Liver Antibodies	>41 publications with B2m and Liver
Heart Antibodies	>30 publications with B2m and Heart
Muscle Antibodies	>28 publications with B2m and Muscle
Brain Antibodies	>27 publications with B2m and Brain
Prostate Antibodies	>18 publications with B2m and Prostate
Spleen Antibodies	>17 publications with B2m and Spleen
Lung Antibodies	>17 publications with B2m and Lung
Colon Antibodies	>13 publications with B2m and Colon
Embryonic Tissue Antibodies	>13 publications with B2m and Embryonic Tissue