MAST CELL CHYMASE (CMA1) Antibody – Mouse Monoclonal

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]

CMA1: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.39; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular matrix; extracellular space; extracellular region; intracellular

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity; peptide binding

Biological Process: interleukin-1 beta biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of angiogenesis; cellular protein metabolic process; regulation of inflammatory response; midbrain development; protein processing; angiotensin maturation; proteolysis