Rat Anti-CD265 Monoclonal Antibody – Cat# MBS212478

CD265 Antibody – Rat Monoclonal

Name: CD265 Antibody; Monoclonal; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS212478
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212478

MBS212478 recognises murine receptor activator of NF Kappa-B (RANK), otherwise known as CD265. CD265 is a member of the tumour necrosis factor (TNF) receptor superfamily and plays an important role in lymph node development and osteoclast differentiation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD265, Monoclonal Antibody

Full Product Name

RAT ANTI MOUSE CD265

Product Gene Name

anti-CD265 antibody

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

LOB14-8

Host

Rat

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0 mg/ml (lot specific)

Specificity

This item recognises murine receptor activator of NF Kappa-B (RANK), otherwise known as CD265. CD265 is a member of the tumour necrosis factor (TNF) receptor superfamily and plays an important role in lymph node development and osteoclast differentiation.

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

66,621 Da

3D Structure

ModBase 3D Structure for O35305

Perservative Stabilisers

0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Immunogen

RANK-Fc fusion protein
Fusion Partners||Cells from immunised lou rat were fused with cells of the mouse NS-1 myeloma cel line.
Buffer Solution||Phosphate buffered saline

Target Species

Mouse

Applications Tested/Suitable for anti-CD265 antibody

ELISA (EIA), Flow cytometry (FC/FACS), Immunoprecipitation (IP)

Application Notes for anti-CD265 antibody

Flow Cytometry: Use 20ul of the suggested working dilution to label 106 cells in 100ul.
ELISA: Maximum Dilution: 20ug/ml
Flow Cytometry: Maximum Dilution: 20ug/ml
Immunoprecipitation: Maximum Dilution: 20ug/ml

Other Notes

Small volumes of anti-CD265 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD265 purchase

MBS212478 is an antibody targeting CD265. Also known as RAT ANTI MOUSE CD265. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD265. It may not necessarily be applicable to this product.

NCBI GI #

110350009

NCBI GeneID

21934

NCBI Accession #

NP_033425.3

UniProt Primary Accession #

O35305

UniProt Secondary Accession #

Q8VCT7

UniProt Related Accession #

O35305

GenBank Nucleotide #

NM_009399.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 11A

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 11a, NFKB activator

NCBI Official Symbol

Tnfrsf11a

NCBI Official Synonym Symbols

OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 11A

UniProt Synonym Protein Names

Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

Tnfrsf11a

UniProt Synonym Gene Names

Rank; ODFR

UniProt Entry Name

TNR11_MOUSE

NCBI Protein Information

tumor necrosis factor receptor superfamily member 11A; osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of NF-kappaB

UniProt Comments for CD265

TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity; transmembrane receptor activity; metal ion binding; cytokine binding

Biological Process: circadian thermoregulation; positive regulation of JNK activity; adaptive immune response; ossification; multicellular organismal development; programmed cell death; response to lipopolysaccharide; osteoclast differentiation; lymph node development; activation of NF-kappaB transcription factor; tumor necrosis factor-mediated signaling pathway; response to cytokine stimulus; positive regulation of transcription factor activity

Research Articles on CD265

1. silencing of miR-503 using a specific antagomir in ovariectomy (OVX) mice increased RANK protein expression, promoted bone resorption

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD265 antibody

Reference Product	PubMed Publications
Tnfsf11 antibody	>1540 publications with CD265 and Tnfsf11
Traf6 antibody	>62 publications with CD265 and Traf6
Traf2 antibody	>15 publications with CD265 and Traf2
Tyrobp antibody	>7 publications with CD265 and Tyrobp
Traf3 antibody	>6 publications with CD265 and Traf3
Tec antibody	>4 publications with CD265 and Tec
Vegfa antibody	>3 publications with CD265 and Vegfa
Btk antibody	>1 publications with CD265 and Btk

Pathways associated with anti-CD265 antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Osteoclast Pathway antibodies	Osteoclast Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Osteoclast Differentiation Pathway antibodies	Osteoclast Differentiation Pathway Diagram
Prolactin Signaling Pathway antibodies	Prolactin Signaling Pathway Diagram
Prolactin Signaling Pathway antibodies	Prolactin Signaling Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram

Diseases associated with anti-CD265 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>883 publications with CD265 and Necrosis
Inflammation Antibodies	>148 publications with CD265 and Inflammation
Cardiovascular Diseases Antibodies	>108 publications with CD265 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>59 publications with CD265 and Breast Neoplasms
Osteitis Deformans Antibodies	>49 publications with CD265 and Osteitis Deformans
Neoplasm Metastasis Antibodies	>40 publications with CD265 and Neoplasm Metastasis
Osteosarcoma Antibodies	>30 publications with CD265 and Osteosarcoma
Kidney Diseases Antibodies	>21 publications with CD265 and Kidney Diseases
Neoplasms, Experimental Antibodies	>19 publications with CD265 and Neoplasms, Experimental
Heart Diseases Antibodies	>17 publications with CD265 and Heart Diseases

Organs/Tissues associated with anti-CD265 antibody

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>78 publications with CD265 and Spleen
Prostate Antibodies	>34 publications with CD265 and Prostate
Mammary Gland Antibodies	>26 publications with CD265 and Mammary Gland
Brain Antibodies	>21 publications with CD265 and Brain
Liver Antibodies	>20 publications with CD265 and Liver
Kidney Antibodies	>18 publications with CD265 and Kidney
Thymus Antibodies	>16 publications with CD265 and Thymus
Intestine Antibodies	>8 publications with CD265 and Intestine