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CD106 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212598

Mouse anti Human CD106 antibody, clone STA recognizes human CD106, a 110kDa cell surface protein predominantly expressed on activated vascular endothelium. CD106, also known as vascular cell adhesion molecule 1 (VCAM-1), is also expressed by several… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD106, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD106
Product Gene Name
anti-CD106 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
STA
Host
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
74,346 Da
OMIM
192225
3D Structure
ModBase 3D Structure for P19320
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen
Cells of the DS6 T-cell line
Fusion Partners||Spleen cells from immunised Balb/c mice were fused with cells of the NS-1 myeloma cell line.
Buffer Solution||Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD106 antibody
Flow cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD106 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100

Testing Data of anti-CD106 antibody

Staining of KM-H2 cells with Mouse anti Human CD106:RPE (MBS213755)
Mouse Anti-CD106 Monoclonal Antibody – Cat# MBS212598

Testing Data of anti-CD106 antibody

Staining of KM-H2 cells with Mouse anti Human CD106
Mouse Anti-CD106 Monoclonal Antibody, Testing Data – Cat# MBS212598

Testing Data of anti-CD106 antibody

Staining of KM-H2 cells with Mouse anti Human CD106: Low Endotoxin (MBS211213)
Mouse Anti-CD106 Monoclonal Antibody, Testing Data – Cat# MBS212598

Other Notes

Small volumes of anti-CD106 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD106 purchase

MBS212598 is an antibody targeting CD106. Also known as MOUSE ANTI HUMAN CD106. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD106. It may not necessarily be applicable to this product.

NCBI GI #
4507875
NCBI GeneID
7412
NCBI Accession #
NP_001069.1
UniProt Primary Accession #
P19320
UniProt Secondary Accession #
Q6NUP8; A8K6R7; B4DKS4; E9PDD1
UniProt Related Accession #
P19320
GenBank Nucleotide #
NM_001078.3
NCBI Official Full Name
vascular cell adhesion protein 1 isoform a
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Official Symbol
VCAM1
NCBI Official Synonym Symbols
CD106; INCAM-100
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
INCAM-100; CD_antigen: CD106
Protein Family
Vascular cell adhesion protein
UniProt Gene Name
VCAM1
UniProt Synonym Gene Names
L1CAM; V-CAM 1; VCAM-1
UniProt Entry Name
VCAM1_HUMAN
NCBI Protein Information
vascular cell adhesion protein 1; CD106 antigen

NCBI Summary for CD106

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for CD106

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; apical part of cell; early endosome; plasma membrane; integral to membrane; podosome; sarcolemma; external side of plasma membrane; filopodium

Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding

Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; heart development; cell-matrix adhesion; cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; leukocyte tethering or rolling; cell adhesion; acute inflammatory response; response to nutrient; aging
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Research Articles on CD106

1. Data show that VCAM-1 (CD106) physically associates with CD44 antigen.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD106 antibody

 Reference Product  PubMed Publications
 CD44 antibody  >14 publications with CD106 and CD44
 ITGA4 antibody  >10 publications with CD106 and ITGA4
 ITGB2 antibody  >6 publications with CD106 and ITGB2
 ITGB1 antibody  >3 publications with CD106 and ITGB1
 VEGFA antibody  >3 publications with CD106 and VEGFA
 SRC antibody  >2 publications with CD106 and SRC
 ITGAD antibody  >1 publications with CD106 and ITGAD

Pathways associated with anti-CD106 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD106 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >86 publications with CD106 and Inflammation
 Cardiovascular Diseases Antibodies  >54 publications with CD106 and Cardiovascular Diseases
 Necrosis Antibodies  >50 publications with CD106 and Necrosis
 Atherosclerosis Antibodies  >42 publications with CD106 and Atherosclerosis
 Kidney Diseases Antibodies  >13 publications with CD106 and Kidney Diseases
 Hypertension Antibodies  >12 publications with CD106 and Hypertension
 Heart Diseases Antibodies  >11 publications with CD106 and Heart Diseases
 Myocardial Ischemia Antibodies  >9 publications with CD106 and Myocardial Ischemia
 Anemia Antibodies  >8 publications with CD106 and Anemia
 Myocardial Infarction Antibodies  >7 publications with CD106 and Myocardial Infarction

Organs/Tissues associated with anti-CD106 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >202 publications with CD106 and Vascular
 Blood Antibodies  >122 publications with CD106 and Blood
 Kidney Antibodies  >24 publications with CD106 and Kidney
 Embryonic Tissue Antibodies  >22 publications with CD106 and Embryonic Tissue
 Brain Antibodies  >20 publications with CD106 and Brain
 Heart Antibodies  >17 publications with CD106 and Heart
 Liver Antibodies  >15 publications with CD106 and Liver
 Lung Antibodies  >13 publications with CD106 and Lung
 Skin Antibodies  >8 publications with CD106 and Skin
 Placenta Antibodies  >8 publications with CD106 and Placenta
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