Rabbit Anti-CRT Polyclonal Antibody – Cat# MBS2126447

Creatine Transporter (CRT) Antibody – Rabbit Polyclonal

Name: CRT Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2126447
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2126447

MBS2126447 is an antibody targeting CRT. Also known as HRP-Linked Polyclonal Antibody to Creatine Transporter (CRT). Reactive in Human. Host: Rabbit. More details

$250 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Creatine Transporter (CRT), Polyclonal Antibody

Full Product Name

HRP-Linked Polyclonal Antibody to Creatine Transporter (CRT)

Product Gene Name

anti-CRT antibody

Product Synonym Names

CRT/Creatine Transporter; SLC6A8; CT1; CRTR; Sodium And Chloride Dependent Creatine Transporter 1; Solute Carrier Family 6 Member 8

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Purity/Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Concentration

>=0.5mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)

Specificity

The antibody is a Rabbit polyclonal Antibody raised against Creatine Transporter (CRT). It has been selected for its ability to recognize CRT in immunohistochemical staining and western blotting.

Preparation and Storage

Store at 4 degree C for frequent use, -20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Unconjugated Antibody: CRT (MBS2126752)
HRP Conjugated Antibody: CRT (MBS2126447)

Molecular Weight

70,523 Da

Chromosome Location

Chromosome: X; NC_000023.10 (152953752..152962048). Location: Xq28

OMIM

300036

3D Structure

ModBase 3D Structure for P48029

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Immunogen

Conjugated small molecules/CP

Sequence of Immunogen

Ala193-Arg207 (Accession # Q9GZQ8), with N-terminal His Tag

Organism Species

Human

Conjugation

HRP

Product Categories/Family for anti-CRT antibody

Signal transduction; Primary, HRP-labeled

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-CRT antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-CRT antibody

WB: 0.5-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-CRT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRT. It may not necessarily be applicable to this product.

NCBI GI #

218563756

NCBI GeneID

6535

NCBI Accession #

NP_001136277.1

UniProt Primary Accession #

P48029

UniProt Secondary Accession #

Q13032; Q66I36; B2KY47; B4DIA3; E9PFC0

UniProt Related Accession #

P48029

GenBank Nucleotide #

NM_001142805.1

NCBI Official Full Name

sodium- and chloride-dependent creatine transporter 1 isoform 2

NCBI Official Synonym Full Names

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

NCBI Official Symbol

SLC6A8

NCBI Official Synonym Symbols

CRT; CT1; CRTR

UniProt Protein Name

Sodium- and chloride-dependent creatine transporter 1

UniProt Synonym Protein Names

Solute carrier family 6 member 8

Protein Family

Chloroquine resistance transporter

UniProt Gene Name

SLC6A8

UniProt Synonym Gene Names

CT1

UniProt Entry Name

SC6A8_HUMAN

NCBI Protein Information

sodium- and chloride-dependent creatine transporter 1; creatine transporter SLC6A8; solute carrier family 6 member 8

NCBI Summary for CRT

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

UniProt Comments for CRT

SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: creatine transporter activity; neurotransmitter:sodium symporter activity; creatine:sodium symporter activity

Biological Process: muscle contraction; neurotransmitter transport; transport; sodium ion transport; creatine metabolic process; creatine transport

Disease: Cerebral Creatine Deficiency Syndrome 1

Research Articles on CRT

1. Missense mutations in SLC6A8 gene is associated with X-linked disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CRT antibody

Products by Pathway	Pathway Diagram
Creatine Metabolism Pathway antibodies	Creatine Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with anti-CRT antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>49 publications with CRT and Nervous System Diseases
Mental Retardation, X-Linked Antibodies	>41 publications with CRT and Mental Retardation, X-Linked
Brain Diseases Antibodies	>27 publications with CRT and Brain Diseases
Seizures Antibodies	>17 publications with CRT and Seizures
Autistic Disorder Antibodies	>9 publications with CRT and Autistic Disorder
Developmental Disabilities Antibodies	>6 publications with CRT and Developmental Disabilities
Creatine deficiency, X-linked Antibodies	>5 publications with CRT and Creatine deficiency, X-linked
Movement Disorders Antibodies	>5 publications with CRT and Movement Disorders
Drug Toxicity Antibodies	>5 publications with CRT and Drug Toxicity
Learning Disorders Antibodies	>4 publications with CRT and Learning Disorders

Organs/Tissues associated with anti-CRT antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>76 publications with CRT and Brain
Blood Antibodies	>28 publications with CRT and Blood
Muscle Antibodies	>16 publications with CRT and Muscle
Kidney Antibodies	>10 publications with CRT and Kidney
Heart Antibodies	>10 publications with CRT and Heart
Liver Antibodies	>4 publications with CRT and Liver
Lung Antibodies	>2 publications with CRT and Lung
Testis Antibodies	>2 publications with CRT and Testis
Eye Antibodies	>2 publications with CRT and Eye
Intestine Antibodies	>2 publications with CRT and Intestine