Mouse Anti-CD88 Monoclonal Antibody – Cat# MBS212653

Staining of rat peripheral blood granulocytes probed with Mouse anti Rat CD88 : RPE (MBS213771)

CD88 Antibody – Mouse Monoclonal

Name: CD88 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS212653
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212653

Mouse anti Rat CD88 antibody, clone R63 recognizes the rat CD88 cell surface receptor, also known as C5aR, which functions as a receptor for the C5a fragment of the complement factor C5. CD88 is expressed by cells of the myeloid lineage such as monocytes and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD88, Monoclonal Antibody

Full Product Name

MOUSE ANTI RAT CD88

Product Gene Name

anti-CD88 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

R63

Host

Mouse

Form/Format

Purified
Purified IgG - liquid

Concentration

IgG concentration 1.0 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Molecular Weight

39,417 Da

3D Structure

ModBase 3D Structure for P97520

Perservative Stabilisers

0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen

Transfectants expressing rat CD88
Histology Positive Control Tissue||Liver
Fusion Partners||Spleen cells from immunised BALB/c mice were fused with cells of the mouse Ag8.653 myeloma cell line
Buffer Solution||Phosphate buffered saline

Target Species

Rat

Applications Tested/Suitable for anti-CD88 antibody

Immunohistology Frozen, Flow cytometry (FC/FACS)

Application Notes for anti-CD88 antibody

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/50

Other Notes

Small volumes of anti-CD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD88 purchase

MBS212653 is an antibody targeting CD88. Also known as MOUSE ANTI RAT CD88. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD88. It may not necessarily be applicable to this product.

NCBI GI #

16758418

NCBI GeneID

113959

NCBI Accession #

NP_446071.1

UniProt Primary Accession #

P97520

UniProt Secondary Accession #

O09088

UniProt Related Accession #

P97520

GenBank Nucleotide #

NM_053619.1

NCBI Official Full Name

C5a anaphylatoxin chemotactic receptor 1

NCBI Official Synonym Full Names

complement component 5a receptor 1

NCBI Official Symbol

C5ar1

NCBI Official Synonym Symbols

C5r1

UniProt Protein Name

C5a anaphylatoxin chemotactic receptor 1

UniProt Synonym Protein Names

C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88

UniProt Gene Name

C5ar1

UniProt Synonym Gene Names

C5r1; C5a-R; C5aR

UniProt Entry Name

C5AR1_RAT

NCBI Protein Information

C5a anaphylatoxin chemotactic receptor 1; C5a-R; C5aR; complement C5a receptor; complement component 5, receptor 1

NCBI Summary for CD88

binds complement component 5 and induces Ca+2 release from intracellular stores [RGD, Feb 2006]

UniProt Comments for CD88

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: cell surface; apical part of cell; basolateral plasma membrane; cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane

Molecular Function: complement component C5a receptor activity; complement component C5a binding; C5a anaphylatoxin receptor activity

Biological Process: neutrophil chemotaxis; organ regeneration; apoptosis; complement receptor mediated signaling pathway; response to lipopolysaccharide; cell proliferation in hindbrain; mRNA transcription from RNA polymerase II promoter; G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; response to peptidoglycan; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation

Research Articles on CD88

1. C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD88 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-CD88 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>43 publications with CD88 and Inflammation
Immune System Diseases Antibodies	>21 publications with CD88 and Immune System Diseases
Cardiovascular Diseases Antibodies	>11 publications with CD88 and Cardiovascular Diseases
Necrosis Antibodies	>8 publications with CD88 and Necrosis
Nervous System Diseases Antibodies	>7 publications with CD88 and Nervous System Diseases
Kidney Diseases Antibodies	>6 publications with CD88 and Kidney Diseases
Eye Diseases Antibodies	>3 publications with CD88 and Eye Diseases
Lung Injury Antibodies	>3 publications with CD88 and Lung Injury
Atherosclerosis Antibodies	>3 publications with CD88 and Atherosclerosis
Fibrosis Antibodies	>3 publications with CD88 and Fibrosis

Organs/Tissues associated with anti-CD88 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>9 publications with CD88 and Lung
Kidney Antibodies	>8 publications with CD88 and Kidney
Brain Antibodies	>5 publications with CD88 and Brain
Connective Tissue Antibodies	>2 publications with CD88 and Connective Tissue