CD26 Antibody – Rat Monoclonal

DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily.

Protein type: Cell surface; Cell adhesion; Membrane protein, integral; EC 3.4.14.5; Protease

Cellular Component: Golgi apparatus; intercellular canaliculus; focal adhesion; cell surface; lysosomal membrane; endoplasmic reticulum; extracellular region; integral to membrane; cell projection; membrane; lamellipodium; endocytic vesicle; apical plasma membrane; plasma membrane; cell junction

Molecular Function: peptidase activity; collagen binding; identical protein binding; protein homodimerization activity; protease binding; hydrolase activity; dipeptidyl-peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; aminopeptidase activity; peptide binding; receptor binding

Biological Process: regulation of cell-cell adhesion mediated by integrin; behavioral fear response; T cell activation; establishment of localization; T cell costimulation; regulation of T cell mediated immunity; positive regulation of cell proliferation; response to hypoxia; endothelial cell migration; cell adhesion; proteolysis