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CD88 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212811

Rat anti Mouse CD88 antibody, clone 10/92 recognizes murine CD88, a 45kD G-protein coupled cell surface receptor, which is otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, which is a potent proinflammatory… More details

$420 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD88, Monoclonal Antibody
Full Product Name
RAT ANTI MOUSE CD88
Product Gene Name
anti-CD88 antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
10/92
Host
Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
39,023 Da
3D Structure
ModBase 3D Structure for P30993
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen
RBL-2H3 transfected cells expressing murine C5aR
Fusion Partners||Cells from immunised Lou/c rats were fused with cells of the X63-Ag8.653 myeloma cell line.
Buffer Solution||Phosphate buffered saline
Target Species
Mouse
Applications Tested/Suitable for anti-CD88 antibody
Immunohistology Frozen, Flow cytometry (FC/FACS)
Application Notes for anti-CD88 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Method sheets available on request.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100

Testing Data of anti-CD88 antibody

Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD88
Rat Anti-CD88 Monoclonal Antibody – Cat# MBS212811

Testing Data of anti-CD88 antibody

Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD88:Alexa Fluor 488 (MBS212810A488)
Rat Anti-CD88 Monoclonal Antibody, Testing Data – Cat# MBS212811

Other Notes

Small volumes of anti-CD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD88 purchase

MBS212811 is an antibody targeting CD88. Also known as RAT ANTI MOUSE CD88. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD88. It may not necessarily be applicable to this product.

NCBI GI #
291167769
NCBI GeneID
12273
NCBI Accession #
NP_001167021.1
UniProt Primary Accession #
P30993
UniProt Secondary Accession #
Q3TZ86
UniProt Related Accession #
P30993
GenBank Nucleotide #
NM_001173550.1
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 1
NCBI Official Synonym Full Names
complement component 5a receptor 1
NCBI Official Symbol
C5ar1
NCBI Official Synonym Symbols
C5aR; C5r1; Cd88; D7Msu1
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 1
UniProt Synonym Protein Names
C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88
UniProt Gene Name
C5ar1
UniProt Synonym Gene Names
C5ar; C5r1; C5a-R; C5aR
UniProt Entry Name
C5AR1_MOUSE
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a-R; complement component 5, receptor 1

UniProt Comments for CD88

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: cell surface; membrane; apical part of cell; basolateral plasma membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; cytosol

Molecular Function: G-protein coupled receptor activity; complement component C5a receptor activity; complement component C5a binding; signal transducer activity; anaphylatoxin receptor activity; C5a anaphylatoxin receptor activity

Biological Process: neutrophil chemotaxis; apoptosis; complement receptor mediated signaling pathway; cell proliferation in hindbrain; signal transduction; chemotaxis; mRNA transcription from RNA polymerase II promoter; G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; response to peptidoglycan; negative regulation of neuron apoptosis; positive regulation of epithelial cell proliferation
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Research Articles on CD88

1. Findings demonstrate that, under excitotoxicity, Fosb products contribute to a neuroinflammatory response in the hippocampus through regulation of microglial C5ar1 and C5ar2 expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD88 antibody

 Reference Product  PubMed Publications
 C3ar1 antibody  >2 publications with CD88 and C3ar1
 Ccl5 antibody  >1 publications with CD88 and Ccl5
 Gnai2 antibody  >1 publications with CD88 and Gnai2

Pathways associated with anti-CD88 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Organs/Tissues associated with anti-CD88 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >7 publications with CD88 and Bone
 Bone Marrow Antibodies  >7 publications with CD88 and Bone Marrow
 Spleen Antibodies  >5 publications with CD88 and Spleen
 Liver Antibodies  >4 publications with CD88 and Liver
 Embryonic Tissue Antibodies  >2 publications with CD88 and Embryonic Tissue
 Skin Antibodies  >1 publications with CD88 and Skin
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